Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1. (Q38846360)

6 September 2017

title

Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1. (English)

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6 September 2017

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mitochondrial fission

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6 September 2017

Giampaolo Morciano

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6 September 2017

Gaia Pedriali

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6 September 2017

Luigi Sbano

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6 September 2017

Tommaso Iannitti

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6 September 2017

Carlotta Giorgi

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6 September 2017

publication date

28 May 2016

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6 September 2017

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inferred from page(s)

published in

Biology of the Cell

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6 September 2017

volume

108

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6 September 2017

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6 September 2017

page(s)

279-293

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Mcl-1 is a potential therapeutic target in multiple types of cancer

6 September 2017

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(De)constructing mitochondria: what for?

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Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.

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21 January 2018

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The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

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ER Tubules Mark Sites of Mitochondrial Division

21 January 2018

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Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

21 January 2018

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Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen

21 January 2018

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

21 January 2018

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Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

21 January 2018

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Mitochondrial Ca(2+) and apoptosis

21 January 2018

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Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications

21 January 2018

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A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition

21 January 2018

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21 January 2018

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CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.

21 January 2018

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Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

21 January 2018

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Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.

21 January 2018

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Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis

21 January 2018

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Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity

21 January 2018

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

21 January 2018

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Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

21 January 2018

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Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

21 January 2018

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Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

21 January 2018

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An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation

21 January 2018

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Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines

21 January 2018

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

21 January 2018

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Role of Bax and Bak in mitochondrial morphogenesis

21 January 2018

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MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FBOC.201600019

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death

21 January 2018

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https://api.crossref.org/works/10.1111%2FBOC.201600019

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

21 January 2018

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Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

21 January 2018

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Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FBOC.201600019

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FBOC.201600019

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

21 January 2018

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Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

21 January 2018

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A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

21 January 2018

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Mitochondrial dynamics in mammalian health and disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FBOC.201600019

Apoptosis and oncogenesis: give and take in the BCL-2 family

21 January 2018

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The dynamic plant chondriome.

21 January 2018

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Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

21 January 2018

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Mitochondria-ros crosstalk in the control of cell death and aging

21 January 2018

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https://api.crossref.org/works/10.1111%2FBOC.201600019

The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.

21 January 2018

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Mitochondrial fusion intermediates revealed in vitro

21 January 2018

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Many players in BCL-2 family affairs

21 January 2018

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Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

21 January 2018

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Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization

21 January 2018

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DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress

21 January 2018

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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FBOC.201600019

MiD49 and MiD51, new components of the mitochondrial fission machinery

21 January 2018

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Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

21 January 2018

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Calcium signaling around Mitochondria Associated Membranes (MAMs).

21 January 2018

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Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

21 January 2018

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Identification of a novel Mcl-1 protein binding motif

21 January 2018

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The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death

21 January 2018

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Mitochondrial Ca(2+) Remodeling is a Prime Factor in Oncogenic Behavior

21 January 2018

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Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo

21 January 2018

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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

21 January 2018

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Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner

21 January 2018

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Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2- and Drp1-dependent manner

21 January 2018

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21 January 2018

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Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia

21 January 2018

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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

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Shared components of mitochondrial and peroxisomal division

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MCL1 is critical for mitochondrial function and autophagy in the heart

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis

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Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

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Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion

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Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

21 January 2018

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Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization

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The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

21 January 2018

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The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1

21 January 2018

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Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

21 January 2018

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BOC.201600019

1 reference

6 September 2017

1 reference