The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion (Q39189628)

9 September 2017

title

The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion (English)

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alternative mRNA splicing, via spliceosome

9 September 2017

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C Braeutigam

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9 September 2017

L Rago

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9 September 2017

A Rolke

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9 September 2017

L Waldmeier

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9 September 2017

G Christofori

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9 September 2017

J Winter

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9 September 2017

language of work or name

English

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publication date

25 February 2013

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

page(s)

1082-1092

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

9 September 2017

cites work

1 reference

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EMT, the cytoskeleton, and cancer cell invasion

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Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT).

21 January 2018

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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

21 January 2018

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Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2.

21 January 2018

1 reference

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A Complex Intronic Splicing Enhancer from the c-src Pre-mRNA Activates Inclusion of a Heterologous Exon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

Fox-1 family of RNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

Cancer-associated regulation of alternative splicing

21 January 2018

1 reference

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Exon-level microarray analyses identify alternative splicing programs in breast cancer

21 January 2018

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Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues

21 January 2018

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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

21 January 2018

1 reference

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Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene.

21 January 2018

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An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing

21 January 2018

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Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

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NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin

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Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo

21 January 2018

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Autoregulation of Fox protein expression to produce dominant negative splicing factors

21 January 2018

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TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.

21 January 2018

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Cortactin: a multifunctional regulator of cellular invasiveness

21 January 2018

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Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

21 January 2018

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Unbalanced alternative splicing and its significance in cancer

21 January 2018

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CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

21 January 2018

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Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion

21 January 2018

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hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration.

21 January 2018

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Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.

21 January 2018

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Regulation of the MID1 protein function is fine-tuned by a complex pattern of alternative splicing

21 January 2018

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Dynamin as a mover and pincher during cell migration and invasion

21 January 2018

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Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma

21 January 2018

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Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion

21 January 2018

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FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGFβ3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.50

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.50

Differential regulation of cell-cell contact, invasion and anoikis by hScrib and hDlg in keratinocytes

21 January 2018

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The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility

21 January 2018

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The loss of tuberin promotes cell invasion through the ß-catenin pathway

21 January 2018

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Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

21 January 2018

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Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner

21 January 2018

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Fibroblast growth factors and their receptors in cancer

21 January 2018

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FGFR2 isoforms support epithelial-stromal interactions in thyroid cancer progression

21 January 2018

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Fibroblast growth factor receptor 2: expression, roles, and potential as a novel molecular target for colorectal cancer

21 January 2018

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In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion

21 January 2018

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Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis

21 January 2018

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31 March 2020

Identifiers

DOI

10.1038/ONC.2013.50

1 reference

9 September 2017

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