Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal (Q24298764)

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language of work or name

English

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publication date

6 January 2011

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6 September 2010

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full work available at URL

7 July 2024

https://www.nature.com/articles/onc2010394.pdf

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Portable Document Format

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https://api.crossref.org/works/10.1038/ONC.2010.394

https://www.nature.com/articles/onc2010394

7 July 2024

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https://api.crossref.org/works/10.1038/ONC.2010.394

7 July 2024

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65-76

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

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The ubiquitin-protein ligase Itch regulates p73 stability

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The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

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The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch

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Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

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Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

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A single point mutation in a group I WW domain shifts its specificity to that of group II WW domains

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

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Dimensions Publication ID

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.394

0 references

1046256379

0 references