FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells (Q39276818)

10 September 2017

title

FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells (English)

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10 September 2017

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B Dikshit

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10 September 2017

K Irshad

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10 September 2017

E Madan

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10 September 2017

N Aggarwal

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10 September 2017

C Sarkar

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10 September 2017

P S Chandra

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10 September 2017

D K Gupta

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10 September 2017

P Chattopadhyay

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10 September 2017

S Sinha

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10 September 2017

K Chosdol

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10 September 2017

language of work or name

English

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publication date

1 August 2013

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

page(s)

3798-3808

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Inflammation and oncogenesis: a vicious connection

10 September 2017

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Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule

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Delineation of a Fat tumor suppressor pathway

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The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

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The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

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Immunohistological localisation of human FAT1 (hFAT) protein in 326 breast cancers. Does this adhesion molecule have a role in pathogenesis?

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The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia

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Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array

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Phenotypic variability of a 4q34-->qter inherited deletion: MRKH syndrome in the daughter, cardiac defect and Fallopian tube cancer in the mother.

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Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

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The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

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Programmed cell death protein 4 (pdcd4): a novel target for antineoplastic therapy?

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Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G

21 January 2018

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Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis

21 January 2018

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Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

21 January 2018

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MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

21 January 2018

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Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

21 January 2018

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A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation

21 January 2018

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Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

21 January 2018

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Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun

21 January 2018

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Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells

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Bucillamine mechanism inhibiting IL-1beta-induced VEGF production from fibroblast-like synoviocytes.

21 January 2018

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The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors.

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The activator protein-1 transcription factor in respiratory epithelium carcinogenesis

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Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma

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Akt phosphorylates and regulates Pdcd4 tumor suppressor protein

21 January 2018

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Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway

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Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation.

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c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

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21 January 2018

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21 January 2018

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21 January 2018

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Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures

21 January 2018

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Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3.

21 January 2018

1 reference

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PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavourable prognosis

21 January 2018

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High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

21 January 2018

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Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

21 January 2018

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New insights into Fat cadherins

21 January 2018

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Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells

21 January 2018

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Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

21 January 2018

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The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals

21 January 2018

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

21 January 2018

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Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression

21 January 2018

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Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo

21 January 2018

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Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

21 January 2018

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Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis

21 January 2018

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An essential role of PDCD4 in progression and malignant proliferation of gastrointestinal stromal tumors.

21 January 2018

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PDCD4 inhibits the malignant phenotype of ovarian cancer cells

21 January 2018

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Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

21 January 2018

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Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy.

21 January 2018

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IGF-1 induced HIF-1α-TLR9 cross talk regulates inflammatory responses in glioma.

21 January 2018

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Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance

21 January 2018

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Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors

21 January 2018

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The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway

21 January 2018

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21 January 2018

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Cancer and inflammation: promise for biologic therapy.

21 January 2018

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Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid

21 January 2018

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An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes

21 January 2018

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From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.

21 January 2018

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Therapy for glioma: Indian perspective.

31 March 2020

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Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets

31 March 2020

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Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth

31 March 2020

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Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer

31 March 2020

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Cyclooxygenase in the treatment of glioma: its complex role in signal transduction

31 March 2020

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Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies.

31 March 2020

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Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.393

Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

31 March 2020

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7 January 2021

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Identifiers

DOI

10.1038/ONC.2012.393

1 reference

Dimensions Publication ID

10 September 2017

1040823784

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Fatcat ID

release_pgind6it3nehdgmx3kqprdqova

0 references

1 reference