Caspase-dependent Mcl-1 cleavage and effect of Mcl-1 phosphorylation in ABT-737-induced apoptosis in human acute lymphoblastic leukemia cell lines. (Q38982534)

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English	Caspase-dependent Mcl-1 cleavage and effect of Mcl-1 phosphorylation in ABT-737-induced apoptosis in human acute lymphoblastic leukemia cell lines.	scientific article

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21 March 2020

Caspase-dependent Mcl-1 cleavage and effect of Mcl-1 phosphorylation in ABT-737-induced apoptosis in human acute lymphoblastic leukemia cell lines (English)

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21 March 2020

lymphoblastic leukemia

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inferred from title

3

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21 March 2020

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21 March 2020

author name string

YongKu Ryu

1

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21 March 2020

Connor P Hall

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20 June 2014

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21 March 2020

Experimental Biology and Medicine

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21 March 2020

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21 March 2020

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1390-1402

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21 March 2020

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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21 January 2018

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

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21 January 2018

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

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21 January 2018

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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

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21 January 2018

Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma

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21 January 2018

Synergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma

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21 January 2018

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

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21 January 2018

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

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21 January 2018

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21 January 2018

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

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21 January 2018

Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

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21 January 2018

Short tandem repeat profiling provides an international reference standard for human cell lines

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21 January 2018

A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

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21 January 2018

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

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21 January 2018

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

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21 January 2018

Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1.

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Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

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21 January 2018

Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

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Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

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21 January 2018

Mcl-1; the molecular regulation of protein function

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Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

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Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis

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10.1177/1535370214538745

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21 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951472%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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