Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. (Q35250940)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200714%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

title

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 (English)

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23 December 2019

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chronic lymphocytic leukemia

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inferred from title

author

Victoria Del Gaizo Moore

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23 December 2019

Jennifer R Brown

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23 December 2019

Michael Certo

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23 December 2019

Tara M Love

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23 December 2019

Carl D Novina

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23 December 2019

Anthony Letai

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23 December 2019

language of work or name

English

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publication date

1 January 2007

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Journal of Clinical Investigation

23 December 2019

published in

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23 December 2019

volume

117

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23 December 2019

issue

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23 December 2019

page(s)

112-121

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The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

23 December 2019

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27 July 2018

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

27 July 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

27 July 2018

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The expanding role of mitochondria in apoptosis

27 July 2018

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

27 July 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

27 July 2018

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Genomic aberrations and survival in chronic lymphocytic leukemia

27 July 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

27 July 2018

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Bax-independent inhibition of apoptosis by Bcl-XL.

27 July 2018

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Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins

27 July 2018

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

27 July 2018

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

27 July 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

27 July 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

26 September 2018

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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

26 September 2018

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Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

26 September 2018

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Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia

26 September 2018

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

26 September 2018

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Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

26 September 2018

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Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

26 September 2018

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26 September 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

26 September 2018

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26 September 2018

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

26 September 2018

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis

26 September 2018

1 reference

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Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.

26 September 2018

1 reference

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Antiapoptotic BCL-2 is required for maintenance of a model leukemia

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17200714

12 December 2020

inferred from PubMed ID database lookup

A matter of life and death

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17200714

12 December 2020

inferred from PubMed ID database lookup

Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17200714

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI28281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200714%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200714%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

PubMed publication ID

17200714

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17200714%20AND%20SRC:MED&resulttype=core&format=json