Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy (Q24635408)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19228717%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

review article

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title

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19228717%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

0 references

1 reference

Min H Kang

1 reference

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21 January 2020

C Patrick Reynolds

1 reference

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21 January 2020

language of work or name

English

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publication date

1 February 2009

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21 January 2020

published in

Clinical Cancer Research

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21 January 2020

volume

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21 January 2020

issue

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21 January 2020

page(s)

1126-1132

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

21 January 2020

cites work

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

7 April 2017

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

7 April 2017

1 reference

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Targeted therapy against Bcl-2-related proteins in breast cancer cells

7 April 2017

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

7 April 2017

1 reference

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BID: a novel BH3 domain-only death agonist

7 April 2017

1 reference

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

7 April 2017

1 reference

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Autophagy fights disease through cellular self-digestion

7 April 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

7 April 2017

1 reference

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Cell death: critical control points

7 April 2017

1 reference

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The Fas signaling pathway: more than a paradigm

7 April 2017

1 reference

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

7 April 2017

1 reference

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

7 April 2017

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 April 2017

1 reference

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Live or let die: the cell's response to p53

7 April 2017

1 reference

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Mitochondria and apoptosis

7 April 2017

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

7 April 2017

1 reference

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

7 April 2017

1 reference

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

7 April 2017

1 reference

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

1 reference

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Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

7 April 2017

1 reference

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Bcl-2-family proteins and hematologic malignancies: history and future prospects

27 September 2017

1 reference

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Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103.

27 September 2017

1 reference

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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

27 September 2017

1 reference

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2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition

27 September 2017

1 reference

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

27 September 2017

1 reference

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Oblimersen and alpha-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium.

27 September 2017

1 reference

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Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

27 September 2017

1 reference

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Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

27 September 2017

1 reference

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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

27 September 2017

1 reference

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

27 September 2017

1 reference

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

27 September 2017

1 reference

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Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

27 September 2017

1 reference

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Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy

27 September 2017

1 reference

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Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

27 September 2017

1 reference

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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Apoptosis-based therapies for hematologic malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182268

Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells.

27 September 2017

1 reference

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Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma

27 September 2017

1 reference

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Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

27 September 2017

1 reference

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Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

27 September 2017

1 reference

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Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

27 September 2017

1 reference

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

27 September 2017

1 reference

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Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

27 September 2017

1 reference

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The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity

27 September 2017

1 reference

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

27 September 2017

1 reference

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An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

30 May 2018

1 reference

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Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2.

30 May 2018

1 reference

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

30 May 2018

1 reference

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

30 May 2018

1 reference

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An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis.

30 May 2018

1 reference

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Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions

28 November 2018

1 reference

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The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

28 November 2018

1 reference

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Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy.

28 November 2018

1 reference

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

28 November 2018

1 reference

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The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

28 November 2018

1 reference

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Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis

28 November 2018

1 reference

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A phase II, pharmacokinetic, and biological correlative study of oblimersen sodium and docetaxel in patients with hormone-refractory prostate cancer

28 November 2018

1 reference

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Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

28 November 2018

1 reference

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Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML).

28 November 2018

1 reference

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Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN.

28 November 2018

1 reference

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

28 November 2018

1 reference

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Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

28 November 2018

1 reference

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High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate

28 November 2018

1 reference

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Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein.

28 November 2018

1 reference

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Expression of bcl-xL can confer a multidrug resistance phenotype

28 November 2018

1 reference

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A phase I-II study of oblimersen sodium (G3139, Genasense) in combination with doxorubicin in advanced hepatocellular carcinoma (NCI # 5798)

28 November 2018

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12 December 2020

Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants

1 reference

12 December 2020

Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines

1 reference

12 December 2020

Expression of BCL-2 proto-oncogene in adult acute lymphoblastic leukemia

1 reference

12 December 2020

Fenretinide: the death of a tumor cell

1 reference

12 December 2020

A Phase II study of Bcl-2 antisense (oblimersen sodium) combined with gemtuzumab ozogamicin in older patients with acute myeloid leukemia in first relapse

1 reference

12 December 2020

Involvement of the bcl-2 gene in human follicular lymphoma

1 reference

12 December 2020

High expression of bcl-2 is the rule in acute lymphoblastic leukemia, except in Burkitt subtype at presentation, and is not correlated with the prognosis

1 reference

12 December 2020

CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM

1 reference

12 December 2020

Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia

1 reference

12 December 2020

10.1158/1078-0432.CCR-08-0144

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19228717%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19228717%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

19228717

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19228717%20AND%20SRC:MED&resulttype=core&format=json