MDMX exerts its oncogenic activity via suppression of retinoblastoma protein (Q38907224)

7 September 2017

title

MDMX exerts its oncogenic activity via suppression of retinoblastoma protein (English)

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7 September 2017

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H Zhang

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7 September 2017

L Hu

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7 September 2017

W Qiu

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7 September 2017

T Deng

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7 September 2017

Y Zhang

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7 September 2017

J Bergholz

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7 September 2017

Z-X Xiao

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7 September 2017

language of work or name

English

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publication date

23 February 2015

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7 September 2017

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7 September 2017

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7 September 2017

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7 September 2017

page(s)

5560-5569

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RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis.

7 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FONC.2015.11

The retinoblastoma tumour suppressor in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

17AAG: low target binding affinity and potent cell activity--finding an explanation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Molecular mechanisms underlying RB protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

RB and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Specific enzymatic dephosphorylation of the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Mdm2-mediated ubiquitylation: p53 and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

MDM2, MDMX and p53 in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

21 January 2018

Modes of p53 regulation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Effects of MdmX on Mdm2-mediated downregulation of pRB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Inactivation of the p53 pathway in retinoblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Comparative study of the p53-mdm2 and p53-MDMX interfaces

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.11

MdmX represses E2F1 transactivation.

31 March 2020

1 reference

12 December 2020

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

12 December 2020

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas

1 reference

12 December 2020

Role of the retinoblastoma protein in differentiation and senescence.

1 reference

12 December 2020

The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin

1 reference

12 December 2020

Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable.

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2015.11

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Dimensions Publication ID

7 September 2017

1025301148

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Fatcat ID

release_vwj5cpu4xbernb26rtobt6tsam

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Fatcat

https://api.fatcat.wiki/v0/release/vwj5cpu4xbernb26rtobt6tsam

24 November 2022

mapped directly with Wikidata item

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