MDMX: a novel p53-binding protein with some functional properties of MDM2 (Q24561971)

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W T Steegenga

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N Riteco

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T van Laar

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P Dekker

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M Bazuine

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R C van Ham

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W van der Houven van Oordt

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G Hateboer

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A J van der Eb

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A G Jochemsen

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

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language of work or name

English

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publication date

1 October 1996

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5349-57

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cites work

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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

24 March 2017

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BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation

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Wild-type p53 binds to the TATA-binding protein and represses transcription

24 March 2017

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A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

24 March 2017

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p53 mutations in human cancers

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Amplification of a gene encoding a p53-associated protein in human sarcomas

24 March 2017

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

24 March 2017

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Physical and functional interaction between WT1 and p53 proteins

24 March 2017

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The p53-mdm-2 autoregulatory feedback loop

24 March 2017

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

24 March 2017

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 April 2017

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

7 April 2017

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mdm2 expression is induced by wild type p53 activity

7 April 2017

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

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Suppression of human colorectal carcinoma cell growth by wild-type p53

7 April 2017

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 April 2017

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Cancer. p53, guardian of the genome

7 April 2017

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

7 April 2017

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T antigen is bound to a host protein in SY40-transformed cells

7 April 2017

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Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

7 April 2017

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p53 binds to the TATA-binding protein-TATA complex.

27 September 2017

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The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein

27 September 2017

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Physical and functional interaction between wild-type p53 and mdm2 proteins

27 September 2017

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The mdm-2 gene is induced in response to UV light in a p53-dependent manner

27 September 2017

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Database of p53 gene somatic mutations in human tumors and cell lines

27 September 2017

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

27 September 2017

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

27 September 2017

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Functional inactivation but not structural mutation of p53 causes liver cancer.

27 September 2017

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A functional p53-responsive intronic promoter is contained within the humanmdm2gene

27 September 2017

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The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

27 September 2017

1 reference

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Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells

27 September 2017

1 reference

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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

27 September 2017

1 reference

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Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

GM1492 human diploid skin fibroblasts lack the p53-dependent G1 cell-cycle checkpoint

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Cytogenetic evolution of mycn and mdm2 amplification in the neuroblastoma ls tumour and its cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Presence of a potent transcription activating sequence in the p53 protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

The status of the p53 gene in human papilloma virus positive or negative cervical carcinoma cell lines

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452278

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

28 November 2018

1 reference

12 December 2020

Regulation of the human hsp70 promoter by p53

1 reference

12 December 2020

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma

1 reference

12 December 2020

The human MDM-2 oncogene is overexpressed in leukemias

1 reference

12 December 2020

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

1 reference

12 December 2020

Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells

1 reference

12 December 2020

Altered patterns of MDM2 and TP53 expression in human bladder cancer

1 reference

12 December 2020

MDM2 overexpression does not account for stabilization of wild-type p53 protein in non-Hodgkin's lymphomas

1 reference

12 December 2020

Human chromosome 11 suppresses the tumorigenicity of adenovirus transformed baby rat kidney cells: involvement of the Wilms' tumor 1 gene

1 reference

12 December 2020

Identifiers

1648300

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference

1648300

PubMed publication ID

8895579

1 reference

Consolidated OpenCitations Corpus – April 2017