Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans (Q27649717)

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1 January 2020

title

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans (English)

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1 January 2020

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1 January 2020

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1 January 2020

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1 January 2020

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1 January 2020

K Linke

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1 January 2020

C A Smith

series ordinal

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1 January 2020

language of work or name

English

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publication date

25 January 2008

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Cell Death & Differentiation

1 January 2020

published in

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1 January 2020

volume

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1 January 2020

issue

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1 January 2020

page(s)

841-848

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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

1 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

MDM2 interacts with MDMX through their RING finger domains

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

The CCP4 suite: programs for protein crystallography

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Automated protein model building combined with iterative structure refinement

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

Coot: model-building tools for molecular graphics

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402309

p53 in health and disease

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

p53 ubiquitination: Mdm2 and beyond

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Regulating the p53 system through ubiquitination

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Regulation of p53 by Mdm2: fate is in the numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Inhibition of p53 degradation by Mdm2 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

MDMX: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

p53 contains large unstructured regions in its native state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402309

21 January 2018

Identifiers

DOI

10.1038/SJ.CDD.4402309

2 references

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

1 January 2020

1024012043

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Fatcat ID

release_fw3rvmkrivclpo33fz3lmvknje

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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