Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors (Q37814176)

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scientific article published on December 2010

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English	Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors	scientific article published on December 2010

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

1 reference

Europe PubMed Central

Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

molecular chaperones

0 references

1 reference

based on heuristic

inferred from title

author name string

Holger Barth

1

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

publication date

1 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

PubMed publication ID

23 August 2017

383

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Europe PubMed Central

PubMed publication ID

23 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

237-245

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Bacterial cytotoxins: targeting eukaryotic switches

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

ADP-ribosylation of actin by clostridial toxins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Identification of residues lining the anthrax protective antigen channel

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Membrane translocation by anthrax toxin

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Isoform-specific inhibition of cyclophilins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Ability of methotrexate to inhibit translocation to the cytosol of dihydrofolate reductase fused to diphtheria toxin

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Protein Translocation through the Anthrax Toxin Transmembrane Pore is Driven by a Proton Gradient

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

How bacterial protein toxins enter cells; the role of partial unfolding in membrane translocation

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Anthrax protective antigen: prepore-to-pore conversion

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Botulinum neurotoxin: a marvel of protein design

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Bacterial protein toxins penetrate cells via a four-step mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Speculation and C2Toxin Production byClostridium botulinumType C Strains Producing No C1Toxin

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

PA63 channel of anthrax toxin: an extended beta-barrel

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Diphtheria toxin entry: protein translocation in the reverse direction

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

A cell-permeable fusion toxin as a tool to study the consequences of actin-ADP-ribosylation caused by the salmonella enterica virulence factor SpvB in intact cells

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Interaction of Diphtheria Toxin T Domain with Molten Globule-Like Proteins and Its Implications for Translocation

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Diphtheria toxin entry into cells is facilitated by low pH.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Prolyl isomerase: enzymatic catalysis of slow protein-folding reactions

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Functional characterization of an extended binding component of the actin-ADP-ribosylating C2 toxin detected in Clostridium botulinum strain (C) 2300.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Clostridium perfringens iota toxin: synergism between two proteins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Intra-endosomal membrane traffic

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

The cyclophilins

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Characterization of membrane translocation by anthrax protective antigen

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Anthrax toxin: receptor binding, internalization, pore formation, and translocation

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Botulinum C2 toxin ADP-ribosylates actin

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0581-Y

21 January 2018

Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[13] Purification and characterization of adenylyl cyclase from Bacillus anthracis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of two components of botulinum C2 toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow conformational changes in protein folding can be accelerated by enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of a biologically active toxin complex of the binary Clostridium botulinum C2 toxin without cell membrane interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated entry of protein toxins into cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes. Formation of cation-selective channels and inhibition of channel function by chloroquine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lethal and vascular permeability activities of botulinum C2 toxin induced by separate injections of the two toxin components.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonmuscle actin ADP-ribosylated by botulinum C2 toxin caps actin filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and action of the binary C2 toxin from Clostridium botulinum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of tissue-cultured cynomolgus monkey kidney cells to botulinum C2 toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways followed by protein toxins into cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolyl isomerases: role in protein folding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological effect of botulinum C2 toxin on mouse intestines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis for the pharmacological actions of Clostridium botulinum type C2 toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological and functional comparison between Clostridium perfringens iota toxin, C. spiroforme toxin, and anthrax toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of cyclosporine (sandimmune). IV. Pharmacological properties in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-ribosylated actin caps the barbed ends of actin filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of botulinum C2 toxin by trypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges

1 reference

https://pubmed.ncbi.nlm.nih.gov/21120455

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-010-0581-Y

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

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