IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice (Q38780046)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28515358%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice (English)

1 reference

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20 March 2020

1 reference

Timothy B Oriss

1 reference

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20 March 2020

Mahesh Raundhal

1 reference

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20 March 2020

Christina Morse

1 reference

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20 March 2020

Rachael E Huff

1 reference

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20 March 2020

Sudipta Das

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20 March 2020

Rachel Hannum

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20 March 2020

Kathryn L Scholl

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20 March 2020

Krishnendu Chakraborty

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20 March 2020

Sally E Wenzel

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20 March 2020

Prabir Ray

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20 March 2020

Anuradha Ray

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20 March 2020

publication date

18 May 2017

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20 March 2020

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20 March 2020

volume

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20 March 2020

issue

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A critical role for IRF5 in regulating allergic airway inflammation.

20 March 2020

cites work

1 reference

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Current concepts of severe asthma

6 September 2017

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Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12

6 September 2017

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STING: infection, inflammation and cancer

6 September 2017

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IRF5 controls both acute and chronic inflammation.

6 September 2017

1 reference

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Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease.

6 September 2017

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Evolving Concepts of Asthma

6 September 2017

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High IFN-γ and low SLPI mark severe asthma in mice and humans

6 September 2017

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Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol

6 September 2017

1 reference

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Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways

6 September 2017

1 reference

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Emerging molecular phenotypes of asthma

6 September 2017

1 reference

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Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma

6 September 2017

1 reference

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An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

6 September 2017

1 reference

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Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.

6 September 2017

1 reference

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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

6 September 2017

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The IRF family transcription factors at the interface of innate and adaptive immune responses

6 September 2017

1 reference

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Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance

6 September 2017

1 reference

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Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.

6 September 2017

1 reference

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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

6 September 2017

1 reference

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Cyclic di-GMP sensing via the innate immune signaling protein STING

6 September 2017

1 reference

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Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses

6 September 2017

1 reference

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Regulating the adaptive immune response to respiratory virus infection

6 September 2017

1 reference

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Asthma outcomes: healthcare utilization and costs

6 September 2017

1 reference

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Sleep quality and asthma control and quality of life in non-severe and severe asthma

6 September 2017

1 reference

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STING is a direct innate immune sensor of cyclic di-GMP

6 September 2017

1 reference

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TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

6 September 2017

1 reference

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

6 September 2017

1 reference

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Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program

6 September 2017

1 reference

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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

6 September 2017

1 reference

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Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses

6 September 2017

1 reference

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Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection.

6 September 2017

1 reference

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Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

6 September 2017

1 reference

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Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation

6 September 2017

1 reference

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Th17 cell differentiation: the long and winding road

6 September 2017

1 reference

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Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response

6 September 2017

1 reference

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

6 September 2017

1 reference

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Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients.

6 September 2017

1 reference

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Negative regulation of Toll-like-receptor signaling by IRF-4.

6 September 2017

1 reference

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Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain

6 September 2017

1 reference

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Interferon-γ: an overview of signals, mechanisms and functions

6 September 2017

1 reference

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Interferon gamma induction of pulmonary emphysema in the adult murine lung

6 September 2017

1 reference

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IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development

6 September 2017

1 reference

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Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13.

6 September 2017

1 reference

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The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

6 September 2017

1 reference

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Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

6 September 2017

1 reference

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

6 September 2017

1 reference

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Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

6 September 2017

1 reference

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Differential regulation of IgG1 and IgE synthesis by interleukin 4.

6 September 2017

1 reference

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Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

6 September 2017

1 reference

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Alveolar macrophages transport pathogens to lung draining lymph nodes

6 September 2017

1 reference

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Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3.

6 September 2017

1 reference

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Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide.

25 September 2017

1 reference

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The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development

25 September 2017

1 reference

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The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity.

25 September 2017

1 reference

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IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

23 June 2018

1 reference

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Degradation of Airway Neuropeptides by Human Lung Tryptase

23 June 2018

1 reference

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Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436536

IRF5:RelA interaction targets inflammatory genes in macrophages

31 August 2018

1 reference

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Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

31 August 2018

1 reference

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Economic burden of impairment in children with severe or difficult-to-treat asthma

31 August 2018

1 reference

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Costs of asthma in the United States: 2002-2007

31 August 2018

1 reference

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Differences in airway cytokine profile in severe asthma compared to moderate asthma.

31 August 2018

1 reference

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IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection

31 August 2018

1 reference

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Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone

31 August 2018

1 reference

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Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi

31 August 2018

1 reference

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Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes

31 August 2018

1 reference

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Requirement for IL-13 independently of IL-4 in experimental asthma

31 August 2018

1 reference

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IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs

31 August 2018

1 reference

12 December 2020

Asthma and allergy: An IFNγ bias in severe asthma

1 reference

12 December 2020

Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation and Tolerance

1 reference

12 December 2020

TH1/TH2 lymphocytes: doubt some more

1 reference

12 December 2020

The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties

1 reference

12 December 2020

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells

1 reference

12 December 2020

10.1172/JCI.INSIGHT.91019

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28515358%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28515358%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

28515358

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28515358%20AND%20SRC:MED&resulttype=core&format=json