Evolving Concepts of Asthma (Q33735605)

29 July 2017

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title

Evolving Concepts of Asthma (English)

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29 July 2017

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Marc Gauthier

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Anuradha Ray

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29 July 2017

Sally E Wenzel

series ordinal

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29 July 2017

language of work or name

English

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publication date

10 July 2015

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American Journal of Respiratory and Critical Care Medicine

29 July 2017

published in

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29 July 2017

volume

192

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29 July 2017

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29 July 2017

page(s)

660-668

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High IFN-γ and low SLPI mark severe asthma in mice and humans

29 July 2017

cites work

1 reference

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Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways

21 June 2018

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Emerging molecular phenotypes of asthma

21 June 2018

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GATA-3 function in innate and adaptive immunity.

21 June 2018

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Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications

21 June 2018

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The nonallergic asthma of obesity. A matter of distal lung compliance

21 June 2018

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Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

21 June 2018

1 reference

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The complex relationship between inflammation and lung function in severe asthma

21 June 2018

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Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program

21 June 2018

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Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma

21 June 2018

1 reference

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Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

21 June 2018

1 reference

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Smoking and asthma: dangerous liaisons.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Obesity and asthma: an inflammatory disease of adipose tissue not the airway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

A large subgroup of mild-to-moderate asthma is persistently noneosinophilic

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Reslizumab for Poorly Controlled, Eosinophilic Asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Lebrikizumab Treatment in Adults with Asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Obesity and asthma: An association modified by age of asthma onset

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Identifying adult asthma phenotypes using a clustering approach

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

On the Capacity of the Lungs, and on the Respiratory Functions, with a View of Establishing a Precise and Easy Method of Detecting Disease by the Spirometer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Mepolizumab and exacerbations of refractory eosinophilic asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Cluster analysis and clinical asthma phenotypes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Clarithromycin targets neutrophilic airway inflammation in refractory asthma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Characterization of within-subject responses to fluticasone and montelukast in childhood asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Anti-immunoglobulin E (omalizumab) therapy in allergic asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/Beclomethasone Study Group

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Cytokines induce the development of functionally heterogeneous T helper cell subsets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Sir John Floyer's A Treatise of the Asthma (1698)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Intolerance to aspirin. Clinical studies and consideration of its pathogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Steroid-dependent asthma treated with inhaled beclomethasone dipropionate. A long-term study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5447293

Asthma: one hundred years of treatment and onward

21 June 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Serial courses of corticotrophin or cortisone in chronic bronchial asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Concerning the nature of intolerance to aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Non-eosinophilic cor ticosteroid unresponsive asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Dupilumab in persistent asthma with elevated eosinophil levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

High eosinophil count: a potential biomarker for assessing successful omalizumab treatment effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Phenotypic predictors of response to oral glucocorticosteroids in severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

High blood eosinophil count is associated with more frequent asthma attacks in asthma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Mortality and Markers of Risk of Asthma Death Among 1,075 Outpatients With Asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Mepolizumab treatment in patients with severe eosinophilic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201504-0763PP

Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids

21 January 2018

1 reference

12 December 2020

Measuring airway inflammation in asthma: Eosinophils and eosinophilic cationic protein in induced sputum compared with peripheral blood

1 reference

12 December 2020

A working classification of asthma

1 reference

12 December 2020

Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma

1 reference

12 December 2020

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

1 reference

12 December 2020

T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma

1 reference

12 December 2020

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12 December 2020

Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum

1 reference

12 December 2020

Clinical value of a tracing of forced expiration (expirogram). I. Pulmonary disease

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12 December 2020

Inhaled corticosteroids compared with oral prednisone in patients starting long-term corticosteroid therapy for asthma. A controlled trial by the British Thoracic and Tuberculosis Association

1 reference

12 December 2020

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

1 reference

12 December 2020

High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma

1 reference

12 December 2020

A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma

1 reference

12 December 2020

1 reference

12 December 2020

Asthma, allergy and steroids

1 reference

12 December 2020

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity

1 reference

12 December 2020

Association of asthma with serum IgE levels and skin-test reactivity to allergens

1 reference

12 December 2020

Other factors besides allergy in asthma

1 reference

12 December 2020

10.1164/RCCM.201504-0763PP

Identifiers

DOI

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29 July 2017

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29 July 2017

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