The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development (Q38774776)

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scientific article published on December 2016

Language	Label	Description	Also known as
English	The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development	scientific article published on December 2016

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

author name string

Frank D Sistare

1

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

William B Mattes

2

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

Edward L LeCluyse

3

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

publication date

1 December 2016

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Europe PubMed Central

PubMed publication ID

6 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

57

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

186-211

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C.

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The significance of mitochondrial toxicity testing in drug development

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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

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Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile

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Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

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Troglitazone-induced liver failure: a case study

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Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

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Clinical development success rates for investigational drugs

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Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity

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Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.

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Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

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21 January 2018

High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells

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21 January 2018

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

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Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

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Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes

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21 January 2018

Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work.

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

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3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

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Chimeric mice with hepatocyte-humanized liver as an appropriate model to study human peroxisome proliferator-activated receptor-α.

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Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

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PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

The collaborative cross: a recombinant inbred mouse population for the systems genetic era.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

A micropatterned hepatocyte coculture model for assessment of liver toxicity using high-content imaging analysis.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Differential mitochondrial toxicity screening and multi-parametric data analysis

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Effects of cell culture conditions on primary rat hepatocytes-cell morphology and differential gene expression

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Long-term stability of primary rat hepatocytes in micropatterned cocultures

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Genetic basis of drug-induced liver injury: present and future

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Metabolomics: a tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Mitochondrial off targets of drug therapy

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

An analysis of the attrition of drug candidates from four major pharmaceutical companies

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Mitochondrial toxicity assessment in industry--a decade of technology development and insight

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Can Humanized Mice Predict Drug "Behavior" in Humans?

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Cellular imaging predictions of clinical drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Deep Learning for Drug-Induced Liver Injury

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Induced pluripotent stem cell lines derived from human somatic cells

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function

1 reference

https://api.crossref.org/works/10.1093%2FILAR%2FILW025

21 January 2018

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

2 references

15 October 2024

https://opencitations.net/index/api/v1/citations/10.14573/ALTEX.1406111

15 October 2024

https://opencitations.net/index/api/v1/citations/10.14573/ALTEX1406111

Identifiers

10.1093/ILAR/ILW025

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

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