Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging (Q40684311)

22 September 2017

title

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging (English)

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22 September 2017

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15 June 2020

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15 June 2020

Jane A Barber

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15 June 2020

Claire Summers

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15 June 2020

Gillian Barrett

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15 June 2020

B Kevin Park

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15 June 2020

John R Foster

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15 June 2020

publication date

27 July 2015

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22 September 2017

published in

Toxicological Sciences

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15 June 2020

volume

148

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issue

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page(s)

48-59

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Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing

15 June 2020

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Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.

21 January 2018

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6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity

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In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

21 January 2018

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Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein

21 January 2018

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6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

21 January 2018

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Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation

21 January 2018

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Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile

21 January 2018

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Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.

21 January 2018

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The use of isolated rat hepatocyte couplets in hepatobiliary physiology

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Cell based approaches for evaluation of drug-induced liver injury.

21 January 2018

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A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

21 January 2018

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High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis

21 January 2018

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Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability

21 January 2018

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Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats

21 January 2018

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Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions

21 January 2018

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Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists

21 January 2018

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Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.

21 January 2018

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Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

21 January 2018

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Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology

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Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes

21 January 2018

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Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

21 January 2018

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Cholyl-lysylfluorescein: synthesis, biliary excretion in vivo and during single-pass perfusion of isolated perfused rat liver

21 January 2018

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Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

21 January 2018

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A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development

21 January 2018

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Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis

21 January 2018

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Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity

21 January 2018

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ANIT-induced disruption of biliary function in rat hepatocyte couplets

21 January 2018

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Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

21 January 2018

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N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes

21 January 2018

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Chapter 4 Preparation of Isolated Rat Liver Cells

21 January 2018

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Dynamic organ culture of precision liver slices for in vitro toxicology.

21 January 2018

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Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.

21 January 2018

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Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.

21 January 2018

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In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFV159

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26220638%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

1 reference

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