Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes (Q38740970)

6 September 2017

title

Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes (English)

1 reference

6 September 2017

1 reference

1 reference

type 2 diabetes

9 December 2023

Kristina Schoonjans

0 references

Ann Marie Zavacki

object named as

Ann M Zavacki

1 reference

6 September 2017

author name string

Oludemilade Akinrotimi

1 reference

6 September 2017

Ryan Riessen

1 reference

6 September 2017

Philip VanDuyne

1 reference

6 September 2017

Jung Eun Park

1 reference

6 September 2017

Yoon Kwang Lee

1 reference

6 September 2017

Lee-Jun Wong

1 reference

6 September 2017

Sayeepriyadarshini Anakk

1 reference

6 September 2017

language of work or name

English

0 references

publication date

6 June 2017

1 reference

6 September 2017

1 reference

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

6 September 2017

cites work

1 reference

Human fatty liver disease: old questions and new insights

21 January 2018

1 reference

Mechanisms for insulin resistance: common threads and missing links

21 January 2018

1 reference

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

21 January 2018

1 reference

Nuclear receptors and the control of metabolism

21 January 2018

1 reference

Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans

21 January 2018

1 reference

Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice

21 January 2018

1 reference

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

21 January 2018

1 reference

Loss of small heterodimer partner protects against atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

1 reference

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

1 reference

Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations

21 January 2018

1 reference

Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

21 January 2018

1 reference

Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

1 reference

Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity

21 January 2018

1 reference

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

21 January 2018

1 reference

Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner

21 January 2018

1 reference

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice

21 January 2018

1 reference

Loss of small heterodimer partner expression in the liver protects against dyslipidemia

21 January 2018

1 reference

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

1 reference

Nuclear receptors reverse McGarry's vicious cycle to insulin resistance

21 January 2018

1 reference

Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

21 January 2018

1 reference

All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.

21 January 2018

1 reference

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

21 January 2018

1 reference

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function

21 January 2018

1 reference

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

21 January 2018

1 reference

The mitochondrial 13513G>A mutation is associated with Leigh disease phenotypes independent of complex I deficiency in muscle

21 January 2018

1 reference

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

21 January 2018

1 reference

Leptin and the regulation of body weight in mammals

21 January 2018

1 reference

Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance

21 January 2018

1 reference

Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse

21 January 2018

1 reference

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

21 January 2018

1 reference

Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice

21 January 2018

1 reference

CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis

21 January 2018

1 reference

Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis

21 January 2018

1 reference

Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver

21 January 2018

1 reference

Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation

21 January 2018

1 reference

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

21 January 2018

1 reference

Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity.

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

21 January 2018

1 reference

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

21 January 2018

1 reference

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

21 January 2018

1 reference

Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage

21 January 2018

1 reference

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 January 2018

1 reference

Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice

21 January 2018

1 reference

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

21 January 2018

1 reference

TGR5-mediated bile acid sensing controls glucose homeostasis

21 January 2018

1 reference

Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/HEP.29305

1 reference

6 September 2017

0 references

1 reference