Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis (Q30433566)

29 September 2017

Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis (English)

1 reference

29 September 2017

Scott A Ochsner

0 references

Neil J McKenna

0 references

Sayeepriyadarshini Anakk

1 reference

29 September 2017

Mitsuhiro Watanabe

1 reference

29 September 2017

Milton J Finegold

1 reference

29 September 2017

David D Moore

1 reference

29 September 2017

language of work or name

English

0 references

publication date

1 December 2010

1 reference

Journal of Clinical Investigation

29 September 2017

1 reference

29 September 2017

121

1 reference

29 September 2017

1 reference

29 September 2017

86-95

1 reference

describes a project that uses

29 September 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3007143

inferred from PubMed Central ID database lookup

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Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy

20 June 2018

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Using GOstats to test gene lists for GO term association

20 June 2018

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"Let there be bile"--understanding hepatic injury in cholestasis

20 June 2018

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

20 June 2018

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Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation

20 June 2018

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Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity

20 June 2018

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

20 June 2018

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The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

20 June 2018

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

20 June 2018

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

20 June 2018

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Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1

20 June 2018

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20 June 2018

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

20 June 2018

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20 June 2018

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Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity

20 June 2018

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Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

20 June 2018

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17-Hydroxycorticosteroid metabolism in liver disease

20 June 2018

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The enzymes, regulation, and genetics of bile acid synthesis

20 June 2018

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

20 June 2018

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Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor

20 June 2018

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Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner

20 June 2018

1 reference

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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic steroid

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Growth, development, and therapeutic considerations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Bile acids: natural ligands for an orphan nuclear receptor

20 June 2018

1 reference

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Identification of a nuclear receptor for bile acids

20 June 2018

1 reference

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The molecular basis of isolated 17,20 lyase deficiency

20 June 2018

1 reference

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Structure and expression of the orphan nuclear receptor SHP gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Proceedings: Metabolism of the hydroxymethylene group in the anabolic steroid, oxymetholone: isolation and identification of two major metabolites.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Increased liver enzymes in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Screening for congenital adrenal hyperplasia: adjustment of 17-hydroxyprogesterone cut-off values to both age and birth weight markedly improves the predictive value

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Resistance of SHP-null mice to bile acid-induced liver damage

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Redundant pathways for negative feedback regulation of bile acid production

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

Intrahepatic cholestasis of pregnancy: A French prospective study

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

The regulation of 17,20 lyase activity

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007143

The Gene Ontology (GO) Project: Structured Vocabularies for Molecular Biology and Their Application to Genome and Expression Analysis

26 November 2018

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12 December 2020

Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures

1 reference

12 December 2020

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12 December 2020

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

1 reference

12 December 2020

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression

1 reference

12 December 2020

Simultaneous determination of bile acids in rat bile and serum by high-performance liquid chromatography

1 reference

12 December 2020

Bile acids, cholesterol, gallstone calcification, and the enterohepatic circulation of bilirubin

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI42846

1 reference

29 September 2017

1 reference

29 September 2017

PubMed publication ID

21123943

1 reference