Regulating excitability of peripheral afferents: emerging ion channel targets (Q38182826)

30 August 2017

title

Regulating excitability of peripheral afferents: emerging ion channel targets (English)

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30 August 2017

Gerald W Zamponi

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Stephen G Waxman

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30 August 2017

language of work or name

English

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publication date

28 January 2014

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30 August 2017

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30 August 2017

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30 August 2017

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30 August 2017

page(s)

153-163

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Calcium-permeable ion channels in pain signaling

30 August 2017

cites work

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Sodium channels and pain

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An SCN9A channelopathy causes congenital inability to experience pain

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Pain perception is altered by a nucleotide polymorphism in SCN9A

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Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

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Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

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A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

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Nociceptors are interleukin-1beta sensors

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Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

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Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.

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NaN/Nav1.9: a sodium channel with unique properties

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The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

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Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

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Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

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Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats

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Virus-mediated shRNA knockdown of Na(v)1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain

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Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.

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Potassium channels: a review of broadening therapeutic possibilities for neurological diseases

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The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

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Distinct potassium channels on pain-sensing neurons

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Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury.

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Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model

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A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

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Kv1.1 channels act as mechanical brake in the senses of touch and pain

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Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

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The neuronal background K2P channels: focus on TREK1

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Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour

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TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons

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TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

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TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury.

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TREK-1, a K+ channel involved in polymodal pain perception

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The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

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Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK

21 January 2018

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Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons

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Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel

21 January 2018

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Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

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A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

21 January 2018

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Ca2+-Activated K+Channels: From Protein Complexes to Function

21 January 2018

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The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system

21 January 2018

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Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons

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A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.

21 January 2018

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BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons

21 January 2018

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Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors

21 January 2018

2 references

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12 December 2020

Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain

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Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons

21 January 2018

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For K+ channels, Na+ is the new Ca2+.

21 January 2018

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Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.

21 January 2018

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PKA-induced internalization of slack KNa channels produces dorsal root ganglion neuron hyperexcitability

21 January 2018

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mTORC2 controls actin polymerization required for consolidation of long-term memory.

21 January 2018

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Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.

21 January 2018

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Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons

21 January 2018

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State-dependent properties of a new T-type calcium channel blocker enhance Ca(V)3.2 selectivity and support analgesic effects

21 January 2018

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A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain.

21 January 2018

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A role for T-type Ca2+ channels in mechanosensation

21 January 2018

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Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse

21 January 2018

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Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons

21 January 2018

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A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis

21 January 2018

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T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures

21 January 2018

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Calcium-activated chloride channels.

21 January 2018

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Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons

21 January 2018

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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels

21 January 2018

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The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

21 January 2018

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HCN channels: function and clinical implications

21 January 2018

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Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder

21 January 2018

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HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression

21 January 2018

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Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.

21 January 2018

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HCN pacemaker channels and pain: a drug discovery perspective

21 January 2018

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A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

21 January 2018

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Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes

21 January 2018

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Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.

21 January 2018

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Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

21 January 2018

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Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation.

21 January 2018

1 reference

HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

21 January 2018

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Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors

21 January 2018

1 reference

12 December 2020

Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor

1 reference

12 December 2020

The reversal potential of Ca(2+)-activated Cl(-) currents indicates that chick sensory neurons accumulate intracellular Cl(-)

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12 December 2020

Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain

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12 December 2020

Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons

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12 December 2020

Changes of sodium channel expression in experimental painful diabetic neuropathy

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12 December 2020

Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy

1 reference

12 December 2020

Involvement of hyperpolarization-activated, cyclic nucleotide-gated cation channels in dorsal root ganglion in neuropathic pain

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12 December 2020

TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing

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12 December 2020

Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons

1 reference

12 December 2020

Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN.3602

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30 August 2017

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