The Na(V)1.7 sodium channel: from molecule to man. (Q38066723)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

review article

1 reference

title

The Na(V)1.7 sodium channel: from molecule to man (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Sulayman D Dib-Hajj

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Joel A Black

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Stephen G Waxman

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

language of work or name

English

0 references

publication date

12 December 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Neuroscience

20 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

49-62

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232607%20AND%20SRC:MED&resulttype=core&format=json

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

20 February 2020

cites work

1 reference

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

31 March 2020

1 reference

The crystal structure of a voltage-gated sodium channel

31 March 2020

1 reference

Signaling complexes of voltage-gated sodium and calcium channels

31 March 2020

1 reference

Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties

31 March 2020

1 reference

Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways.

31 March 2020

1 reference

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

31 March 2020

1 reference

Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.

31 March 2020

1 reference

Differential slow inactivation and use-dependent inhibition of Nav1.8 channels contribute to distinct firing properties in IB4+ and IB4- DRG neurons.

31 March 2020

1 reference

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

31 March 2020

1 reference

Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

31 March 2020

1 reference

Transfection of rat or mouse neurons by biolistics or electroporation

31 March 2020

1 reference

Sodium channels in normal and pathological pain

31 March 2020

1 reference

Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons

31 March 2020

1 reference

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.

31 March 2020

1 reference

Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons

31 March 2020

1 reference

The molecular basis of acid insensitivity in the African naked mole-rat

31 March 2020

1 reference

Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

31 March 2020

1 reference

Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system

31 March 2020

1 reference

Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs

31 March 2020

1 reference

Sodium current in human jejunal circular smooth muscle cells

31 March 2020

1 reference

Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A.

31 March 2020

1 reference

Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes

31 March 2020

1 reference

Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein

31 March 2020

1 reference

Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.

31 March 2020

1 reference

A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo.

31 March 2020

1 reference

Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.

31 March 2020

1 reference

Tetrodotoxin-sensitive Na+ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts

31 March 2020

1 reference

Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset

31 March 2020

1 reference

The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons

31 March 2020

1 reference

Nav1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas

31 March 2020

1 reference

Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn

31 March 2020

1 reference

Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.

31 March 2020

1 reference

Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells

31 March 2020

1 reference

Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons

31 March 2020

1 reference

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

31 March 2020

1 reference

From genes to pain: Na v 1.7 and human pain disorders

31 March 2020

1 reference

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

31 March 2020

1 reference

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

31 March 2020

1 reference

Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.

31 March 2020

1 reference

Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

31 March 2020

1 reference

Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons

31 March 2020

1 reference

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

31 March 2020

1 reference

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

31 March 2020

1 reference

Two novel SCN9A mutations causing insensitivity to pain

31 March 2020

1 reference

Targeting primary afferent nerves for novel antitussive therapy

31 March 2020

1 reference

Experimental and Modeling Study of Na+Current Heterogeneity in Rat Nodose Neurons and Its Impact on Neuronal Discharge

31 March 2020

1 reference

Differential sensitivity to tetrodotoxin and lack of effect of prostaglandin E2 on the pharmacology and physiology of propagated action potentials

31 March 2020

1 reference

Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber)

31 March 2020

1 reference

A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome

31 March 2020

1 reference

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders

31 March 2020

1 reference

Sodium channels and mechanisms of neuropathic pain

31 March 2020

1 reference

Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model

31 March 2020

1 reference

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.

31 March 2020

1 reference

ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties

31 March 2020

1 reference

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

31 March 2020

1 reference

Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat.

31 March 2020

1 reference

Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy

31 March 2020

1 reference

Vector‐mediated release of GABA attenuates pain‐related behaviors and reduces NaV1.7 in DRG neurons

31 March 2020

1 reference

Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents

31 March 2020

1 reference

Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy

31 March 2020

1 reference

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

31 March 2020

1 reference

Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury

31 March 2020

1 reference

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

31 March 2020

1 reference

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

31 March 2020

1 reference

An SCN9A channelopathy causes congenital inability to experience pain

31 March 2020

1 reference

A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

31 March 2020

1 reference

Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability.

31 March 2020

1 reference

Paroxysmal extreme pain disorder (previously familial rectal pain syndrome)

31 March 2020

1 reference

Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons

31 March 2020

1 reference

NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders.

31 March 2020

1 reference

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

31 March 2020

1 reference

Membrane properties and electrogenesis in the distal axons of small dorsal root ganglion neurons in vitro

31 March 2020

1 reference

Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation

31 March 2020

1 reference

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

31 March 2020

1 reference

A stop codon mutation in SCN9A causes lack of pain sensation

31 March 2020

1 reference

A nonsense mutation in the SCN9A gene in congenital insensitivity to pain

31 March 2020

1 reference

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

31 March 2020

1 reference

On the allelic spectrum of human disease

31 March 2020

1 reference

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

31 March 2020

1 reference

Pain perception is altered by a nucleotide polymorphism in SCN9A

31 March 2020

1 reference

Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7.

31 March 2020

1 reference

Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study

31 March 2020

1 reference

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

31 March 2020

1 reference

The open pore conformation of potassium channels

31 March 2020

1 reference

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

31 March 2020

1 reference

A prokaryotic voltage-gated sodium channel

31 March 2020

1 reference

NaChBac: the long lost sodium channel ancestor

31 March 2020

1 reference

Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating

31 March 2020

1 reference

Myasthenic syndrome caused by mutation of the SCN4A sodium channel

31 March 2020

1 reference

A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.

31 March 2020

1 reference

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

31 March 2020

1 reference

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

31 March 2020

1 reference

Gating of the ATP-sensitive K+ channel by a pore-lining phenylalanine residue

31 March 2020

1 reference

Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy.

31 March 2020

1 reference

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

31 March 2020

1 reference

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

31 March 2020

1 reference

Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons.

31 March 2020

1 reference

Subtype-selective targeting of voltage-gated sodium channels

31 March 2020

1 reference

Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.

31 March 2020

1 reference

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

31 March 2020

1 reference

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

31 March 2020

1 reference

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

31 March 2020

1 reference

Imidazopyridines: A novel class of hNav1.7 channel blockers

31 March 2020

1 reference

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

31 March 2020

1 reference

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain.

31 March 2020

1 reference

New treatments for neuropathic pain

31 March 2020

1 reference

Pharmacologic management of neuropathic pain: evidence-based recommendations

31 March 2020

1 reference

Are sodium channel blockers useless in peripheral neuropathic pain?

31 March 2020

1 reference

Sensory and motor complications of local anesthetics

31 March 2020

1 reference

Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy

31 March 2020

1 reference

Antinociceptive efficacy of lacosamide in rat models for tumor- and chemotherapy-induced cancer pain

31 March 2020

1 reference

Lacosamide, a new anti-epileptic, alleviates neuropathic pain-like behaviors in rat models of spinal cord or trigeminal nerve injury.

31 March 2020

1 reference

Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy

31 March 2020

1 reference

31 March 2020

1 reference

Lacosamide in painful diabetic peripheral neuropathy: a phase 2 double-blind placebo-controlled study

31 March 2020

1 reference

Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine

31 March 2020

1 reference

Change in excitability and phenotype of substance P and its receptor in cat Abeta sensory neurons following peripheral inflammation

31 March 2020

1 reference

Recommendations for the pharmacological management of neuropathic pain: an overview and literature update

31 March 2020

1 reference

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

31 March 2020

1 reference

Conus venom peptide pharmacology

31 March 2020

1 reference

Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment

31 March 2020

1 reference

Two tarantula peptides inhibit activation of multiple sodium channels

31 March 2020

1 reference

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation

31 March 2020

1 reference

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

31 March 2020

1 reference

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

31 March 2020

1 reference

Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA.

31 March 2020

1 reference

Cyclization of conotoxins to improve their biopharmaceutical properties.

31 March 2020

1 reference

Gene therapy for pain: results of a phase I clinical trial

31 March 2020

1 reference

How the olfactory system makes sense of scents

31 March 2020

1 reference

Olfactory signalling in vertebrates and insects: differences and commonalities

31 March 2020

1 reference

An analysis of Na+ currents in rat olfactory receptor neurons

31 March 2020

1 reference

Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

31 March 2020

1 reference

Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons.

31 March 2020

1 reference

Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury.

31 March 2020

1 reference

Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia

31 March 2020

1 reference

Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade

31 March 2020

1 reference

31 March 2020

1 reference

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23232607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Virus-mediated shRNA knockdown of Na(v)1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23232607