Alternative splicing: a pivotal step between eukaryotic transcription and translation (Q38079475)

28 August 2017

title

Alternative splicing: a pivotal step between eukaryotic transcription and translation (English)

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alternative mRNA splicing, via spliceosome

28 August 2017

main subject

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Mariano Alló

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Gwendal Dujardin

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Alberto R Kornblihtt

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Ignacio E Schor

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28 August 2017

Mariano Alló

series ordinal

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28 August 2017

Ezequiel Petrillo

series ordinal

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28 August 2017

Manuel J Muñoz

series ordinal

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28 August 2017

publication date

6 February 2013

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Nature Reviews Molecular Cell Biology

28 August 2017

published in

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

153-165

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An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

28 August 2017

cites work

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Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

31 March 2020

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Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

31 March 2020

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Deciphering the splicing code

31 March 2020

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Expansion of the eukaryotic proteome by alternative splicing

31 March 2020

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Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

31 March 2020

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Breaking the second genetic code

31 March 2020

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Alternative splicing: new insights from global analyses

31 March 2020

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trans and cis splicing in trypanosomatids: mechanism, factors, and regulation

31 March 2020

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Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae.

31 March 2020

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Sex determination in insects: a binary decision based on alternative splicing.

31 March 2020

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Complex alternative splicing

31 March 2020

2 references

31 March 2020

12 December 2020

Alternative splicing and evolution: diversification, exon definition and function

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The evolution of metazoan extracellular matrix

31 March 2020

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Defining the roles and interactions of PTB.

31 March 2020

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Evolution of Nova-dependent splicing regulation in the brain

31 March 2020

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An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons

31 March 2020

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An RNA map predicting Nova-dependent splicing regulation

31 March 2020

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Searching for splicing motifs.

31 March 2020

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SR proteins and related factors in alternative splicing.

31 March 2020

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hnRNP proteins and splicing control.

31 March 2020

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Influence of RNA secondary structure on the pre-mRNA splicing process

31 March 2020

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Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons

31 March 2020

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Splice site selection, rate of splicing, and alternative splicing on nascent transcripts

31 March 2020

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Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila

31 March 2020

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Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells

31 March 2020

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Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast

31 March 2020

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Co-transcriptional splicing of constitutive and alternative exons

31 March 2020

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Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast

31 March 2020

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Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs

31 March 2020

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Global Analysis of Nascent RNA Reveals Transcriptional Pausing in Terminal Exons

31 March 2020

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Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain

31 March 2020

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SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.

31 March 2020

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Single-molecule imaging of transcriptionally coupled and uncoupled splicing

31 March 2020

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Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions

31 March 2020

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Functional coupling of transcription and splicing

31 March 2020

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An extensive network of coupling among gene expression machines

31 March 2020

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Concurrent splicing and transcription are not sufficient to enhance splicing efficiency

31 March 2020

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The splicing factor SC35 has an active role in transcriptional elongation

31 March 2020

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Splicing-dependent RNA polymerase pausing in yeast

31 March 2020

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Pre-mRNA splicing is a determinant of histone H3K36 methylation

31 March 2020

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Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.

31 March 2020

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The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

31 March 2020

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Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

31 March 2020

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Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer

31 March 2020

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Functional association between promoter structure and transcript alternative splicing.

31 March 2020

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Promoter architecture modulates CFTR exon 9 skipping

31 March 2020

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Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing

31 March 2020

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Transcriptional activators differ in their abilities to control alternative splicing

31 March 2020

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Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes

31 March 2020

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CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing

31 March 2020

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Coordinate regulation of transcription and splicing by steroid receptor coregulators

31 March 2020

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Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation

31 March 2020

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Multiple links between transcription and splicing

31 March 2020

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The human SWI/SNF subunit Brm is a regulator of alternative splicing

31 March 2020

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Control of alternative splicing through siRNA-mediated transcriptional gene silencing.

31 March 2020

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Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing.

31 March 2020

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Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

31 March 2020

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Regulation of alternative splicing by histone modifications

31 March 2020

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Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing

31 March 2020

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The carboxy terminal domain of RNA polymerase II and alternative splicing

31 March 2020

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RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.

31 March 2020

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Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1

31 March 2020

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Mediator complex regulates alternative mRNA processing via the MED23 subunit.

31 March 2020

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Co-transcriptional commitment to alternative splice site selection.

31 March 2020

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Influence of polymerase II processivity on alternative splicing depends on splice site strength.

31 March 2020

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Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation

31 March 2020

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

31 March 2020

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A conserved role for intragenic DNA methylation in alternative pre-mRNA splicing

31 March 2020

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DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

31 March 2020

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The transcriptional cycle of HIV-1 in real-time and live cells.

31 March 2020

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A slow RNA polymerase II affects alternative splicing in vivo

31 March 2020

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TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.

31 March 2020

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First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removal

31 March 2020

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Cotranscriptional exon skipping in the genotoxic stress response

31 March 2020

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Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors

31 March 2020

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CELF proteins regulate CFTR pre-mRNA splicing: essential role of the divergent domain of ETR-3.

31 March 2020

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Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation

31 March 2020

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In vivo dynamics of RNA polymerase II transcription.

31 March 2020

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DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

31 March 2020

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Chromatin and Alternative Splicing

31 March 2020

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Epigenetics in alternative pre-mRNA splicing

31 March 2020

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SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster

31 March 2020

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Differential chromatin marking of introns and expressed exons by H3K36me3.

31 March 2020

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Argonaute proteins couple chromatin silencing to alternative splicing.

31 March 2020

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Nucleosomes are well positioned in exons and carry characteristic histone modifications

31 March 2020

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Chromatin organization marks exon-intron structure

31 March 2020

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Biased chromatin signatures around polyadenylation sites and exons

31 March 2020

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Nucleosome positioning as a determinant of exon recognition

31 March 2020

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Exon recognition in vertebrate splicing

31 March 2020

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Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II.

31 March 2020

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Nascent transcript sequencing visualizes transcription at nucleotide resolution

31 March 2020

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Tissue-specific alternative splicing remodels protein-protein interaction networks

31 March 2020

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Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks

31 March 2020

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An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming

31 March 2020

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Evolution of a tissue-specific splicing network

31 March 2020

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Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform

31 March 2020

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Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats

31 March 2020

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Global analysis of alternative splicing differences between humans and chimpanzees

31 March 2020

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The evolutionary landscape of alternative splicing in vertebrate species

31 March 2020

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Degrade, move, regroup: signaling control of splicing proteins

31 March 2020

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Signals, pathways and splicing regulation

31 March 2020

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Signal-dependent regulation of splicing via phosphorylation of Sam68

31 March 2020

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Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

31 March 2020

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Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT

31 March 2020

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The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus

31 March 2020

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WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

31 March 2020

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The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation

31 March 2020

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Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing

31 March 2020

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Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain.

31 March 2020

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Perturbation of chromatin structure globally affects localization and recruitment of splicing factors

31 March 2020

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Alternative splicing in disease.

31 March 2020

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The connection between splicing and cancer.

31 March 2020

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Cancer-associated regulation of alternative splicing

31 March 2020

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Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

31 March 2020

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Missed threads. The impact of pre-mRNA splicing defects on clinical practice.

31 March 2020

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Genomic variants in exons and introns: identifying the splicing spoilers

31 March 2020

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Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1

31 March 2020

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The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

31 March 2020

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Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

31 March 2020

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

31 March 2020

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A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro

31 March 2020

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The spliceosome: design principles of a dynamic RNP machine

31 March 2020

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An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects

31 March 2020

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Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

31 March 2020

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Antisense-mediated exon inclusion

31 March 2020

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Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

31 March 2020

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Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

31 March 2020

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Cross-kingdom patterns of alternative splicing and splice recognition

31 March 2020

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Alternative splicing of pre-messenger RNAs in plants in the genomic era.

31 March 2020

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Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis

31 March 2020

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Alternative splicing and proteome diversity in plants: the tip of the iceberg has just emerged

31 March 2020

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Alternative splicing and mRNA levels of the disease resistance gene RPS4 are induced during defense responses

31 March 2020

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Alternative splicing: enhancing ability to cope with stress via transcriptome plasticity.

31 March 2020

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RNA regulation in plant abiotic stress responses

31 March 2020

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A methyl transferase links the circadian clock to the regulation of alternative splicing

31 March 2020

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31 March 2020

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Plastids are major regulators of light signaling in Arabidopsis

31 March 2020

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Alternative splicing in plant defense.

31 March 2020

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PubMed

12 December 2020

Drosophila RNA polymerase II mutants that affect transcription elongation

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PubMed

12 December 2020

Regulation of alternative splicing by signal transduction pathways

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PubMed

12 December 2020

Identifiers

DOI

10.1038/NRM3525

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Dimensions Publication ID

28 August 2017

1044635250

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Fatcat ID

release_qmgwme76jjft3apuk26pxxmclq

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Fatcat

https://api.fatcat.wiki/v0/release/qmgwme76jjft3apuk26pxxmclq

24 November 2022

mapped directly with Wikidata item

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