Cotranscriptional exon skipping in the genotoxic stress response (Q39640414)

13 September 2017

title

Cotranscriptional exon skipping in the genotoxic stress response (English)

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13 September 2017

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Gwendal Dujardin

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Laurent Corcos

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Martin Dutertre

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13 September 2017

Gabriel Sanchez

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13 September 2017

Marie-Cécile De Cian

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13 September 2017

Jérôme Barbier

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13 September 2017

Etienne Dardenne

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13 September 2017

Lise Gratadou

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13 September 2017

Catherine Le Jossic-Corcos

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13 September 2017

Didier Auboeuf

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13 September 2017

language of work or name

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24 October 2010

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Nature Structural & Molecular Biology

13 September 2017

published in

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13 September 2017

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13 September 2017

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13 September 2017

page(s)

1358-1366

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The link between mRNA processing and transcription: communication works both ways

13 September 2017

cites work

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Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes.

21 January 2018

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Coupled in vitro synthesis and splicing of RNA polymerase II transcripts

21 January 2018

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Functional coupling of RNAP II transcription to spliceosome assembly

21 January 2018

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Function of alternative splicing

21 January 2018

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A slow RNA polymerase II affects alternative splicing in vivo

21 January 2018

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DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

21 January 2018

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CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing

21 January 2018

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Splicing potentiation by growth factor signals via estrogen receptor phosphorylation

21 January 2018

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The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription.

21 January 2018

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Transcriptional consequences of topoisomerase inhibition

21 January 2018

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RNA polymerase II blockage by cisplatin-damaged DNA. Stability and polyubiquitylation of stalled polymerase

21 January 2018

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The p53 response to DNA damage

21 January 2018

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A functional p53-responsive intronic promoter is contained within the humanmdm2gene

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Alternative and aberrant splicing of MDM2 mRNA in human cancer

21 January 2018

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Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

21 January 2018

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Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

21 January 2018

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Regulation of hdm2 by stress-induced hdm2alt1 in tumor and nontumorigenic cell lines correlating with p53 stability

21 January 2018

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Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage

21 January 2018

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Promoter usage and alternative splicing

21 January 2018

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Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.

21 January 2018

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EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.

21 January 2018

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Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

21 January 2018

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Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs

21 January 2018

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UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation

21 January 2018

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Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo

21 January 2018

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The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription

21 January 2018

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Discovery of tissue-specific exons using comprehensive human exon microarrays

21 January 2018

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Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasis

21 January 2018

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Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

21 January 2018

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A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing

21 January 2018

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Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer

21 January 2018

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TLS, EWS and TAF15: a model for transcriptional integration of gene expression

21 January 2018

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The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4.

21 January 2018

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Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

21 January 2018

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Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

21 January 2018

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Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1

21 January 2018

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Rapid, transcript-specific changes in splicing in response to environmental stress

21 January 2018

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The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links

21 January 2018

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Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress.

21 January 2018

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Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo

21 January 2018

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Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)

21 January 2018

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In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site

21 January 2018

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A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation

21 January 2018

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Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression

21 January 2018

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Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C.

21 January 2018

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A new advance in alternative splicing databases: from catalogue to detailed analysis of regulation of expression and function of human alternative splicing variants.

21 January 2018

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Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells

21 January 2018

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Transcription - guarding the genome by sensing DNA damage

31 March 2020

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An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

31 March 2020

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A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

31 March 2020

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EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing

31 March 2020

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Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors

31 March 2020

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Promoter architecture modulates CFTR exon 9 skipping

31 March 2020

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Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells

31 March 2020

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12 December 2020

The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382.

1 reference

12 December 2020

Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms

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12 December 2020

The intranuclear site of excision of each intron in Balbiani ring 3 pre-mRNA is influenced by the time remaining to transcription termination and different excision efficiencies for the various introns.

1 reference

12 December 2020

Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein

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12 December 2020

Identifiers

DOI

10.1038/NSMB.1912

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13 September 2017

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