The complex world of WNT receptor signalling (Q38059785)

28 August 2017

title

The complex world of WNT receptor signalling (English)

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28 August 2017

Christof Niehrs

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28 August 2017

language of work or name

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15 November 2012

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Nature Reviews Molecular Cell Biology

28 August 2017

published in

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

767-779

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Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

28 August 2017

cites work

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Structural basis of Wnt recognition by Frizzled

31 March 2020

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On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes

31 March 2020

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Wnt signaling in mammalian development: lessons from mouse genetics

31 March 2020

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WNTing embryonic stem cells

31 March 2020

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Wnt/Wingless signaling in Drosophila

31 March 2020

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31 March 2020

Wnt signaling in cancer

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Alternative wnt signaling is initiated by distinct receptors.

31 March 2020

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31 March 2020

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The many roles of PTK7: A versatile regulator of cell–cell communication

31 March 2020

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Ryks: new partners for Wnts in the developing and regenerating nervous system

31 March 2020

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Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor

31 March 2020

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New insights into the mechanism of Wnt signaling pathway activation

31 March 2020

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

31 March 2020

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Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

31 March 2020

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

31 March 2020

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

31 March 2020

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

31 March 2020

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

31 March 2020

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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

31 March 2020

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Function and biological roles of the Dickkopf family of Wnt modulators

31 March 2020

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The tangled web of non-canonical Wnt signalling in neural migration

31 March 2020

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Planar cell polarity signaling: from fly development to human disease

31 March 2020

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Wnt/Ca2+ signaling pathway: a brief overview

31 March 2020

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Wnt trafficking: new insights into Wnt maturation, secretion and spreading

31 March 2020

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Mitotic and mitogenic Wnt signalling

31 March 2020

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TCFs and Wnt/β-catenin signaling: more than one way to throw the switch

31 March 2020

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Wnt signalling in stem cells and cancer

31 March 2020

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Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos

31 March 2020

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Identification of targets of the Wnt pathway destruction complex in addition to beta-catenin

31 March 2020

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Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes

31 March 2020

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Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

31 March 2020

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The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

31 March 2020

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Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

31 March 2020

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Wnt5a regulates distinct signalling pathways by binding to Frizzled2

31 March 2020

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Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling

31 March 2020

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Wnt proteins are lipid-modified and can act as stem cell growth factors

31 March 2020

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Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

31 March 2020

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Lipoprotein particles are required for Hedgehog and Wingless signalling

31 March 2020

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Mammalian Wnt3a is released on lipoprotein particles

31 March 2020

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Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization

31 March 2020

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31 March 2020

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

31 March 2020

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A new secreted protein that binds to Wnt proteins and inhibits their activities

31 March 2020

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Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless

31 March 2020

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Yellow submarine of the Wnt/Frizzled signaling: submerging from the G protein harbor to the targets.

31 March 2020

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Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity

31 March 2020

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Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

31 March 2020

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Mutational analysis of Norrin-Frizzled4 recognition

31 March 2020

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TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling

31 March 2020

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The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

31 March 2020

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

31 March 2020

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Dishevelled: The hub of Wnt signaling

31 March 2020

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The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye.

31 March 2020

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Phosphorylation of frizzled-3.

31 March 2020

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Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

31 March 2020

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Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis

31 March 2020

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Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling

31 March 2020

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Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

31 March 2020

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

31 March 2020

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A mechanism for Wnt coreceptor activation

31 March 2020

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G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

31 March 2020

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Parathyroid hormone signaling through low-density lipoprotein-related protein 6

31 March 2020

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Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

31 March 2020

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Cell cycle control of wnt receptor activation

31 March 2020

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

31 March 2020

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Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation

31 March 2020

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Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation

31 March 2020

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Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

31 March 2020

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Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

31 March 2020

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Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

31 March 2020

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Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes

31 March 2020

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Ror receptor tyrosine kinases: orphans no more

31 March 2020

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Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling

31 March 2020

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The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway

31 March 2020

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Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase

31 March 2020

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Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.

31 March 2020

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Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.

31 March 2020

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Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2

31 March 2020

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Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

31 March 2020

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The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon

31 March 2020

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Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

31 March 2020

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PTK7 recruits dsh to regulate neural crest migration

31 March 2020

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PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling

31 March 2020

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Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling

31 March 2020

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Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

31 March 2020

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Wnt-mediated axon guidance via the Drosophila Derailed receptor

31 March 2020

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The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling

31 March 2020

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Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

31 March 2020

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Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements

31 March 2020

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Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system

31 March 2020

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Initiation of synapse formation by Wnt-induced MuSK endocytosis

31 March 2020

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Wnt proteins regulate acetylcholine receptor clustering in muscle cells

31 March 2020

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Wnt4 participates in the formation of vertebrate neuromuscular junction

31 March 2020

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Biglycan is an extracellular MuSK binding protein important for synapse stability

31 March 2020

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Specificities of heparan sulphate proteoglycans in developmental processes

31 March 2020

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Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

31 March 2020

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Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4

31 March 2020

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Heparan sulphate proteoglycans: the sweet side of development

31 March 2020

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Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos.

31 March 2020

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HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient

31 March 2020

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A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway

31 March 2020

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Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling

31 March 2020

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Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

31 March 2020

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Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate

31 March 2020

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Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase

31 March 2020

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

31 March 2020

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LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

31 March 2020

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Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

31 March 2020

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A critical role for endocytosis in Wnt signaling

31 March 2020

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Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation.

31 March 2020

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Internalization is required for proper Wingless signaling in Drosophila melanogaster

31 March 2020

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Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements

31 March 2020

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Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling

31 March 2020

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Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling

31 March 2020

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Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.

31 March 2020

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Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling

31 March 2020

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

31 March 2020

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Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density

31 March 2020

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R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

31 March 2020

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R-Spondin family members regulate the Wnt pathway by a common mechanism

31 March 2020

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R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

31 March 2020

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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

31 March 2020

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LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling

31 March 2020

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Wnt signaling: multivesicular bodies hold GSK3 captive

31 March 2020

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LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα s

31 March 2020

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The in vitro and in vivo phosphotyrosine map of activated MuSK.

31 March 2020

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Mitogenic influence of human R-spondin1 on the intestinal epithelium

31 March 2020

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The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia

31 March 2020

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R-spondin1 is essential in sex determination, skin differentiation and malignancy.

31 March 2020

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R-spondin3 is required for mouse placental development

31 March 2020

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The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

31 March 2020

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R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

31 March 2020

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Coat variation in the domestic dog is governed by variants in three genes

31 March 2020

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Recurrent R-spondin fusions in colon cancer

31 March 2020

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Secreted and transmembrane wnt inhibitors and activators

31 March 2020

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12 December 2020

The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation

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12 December 2020

Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases

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12 December 2020

A study on the interactions between heparan sulfate proteoglycans and Wnt proteins.

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12 December 2020

The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling

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12 December 2020

β-catenin-dependent Wnt signaling in C. elegans: teaching an old dog a new trick

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12 December 2020

Identifiers

DOI

10.1038/NRM3470

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Dimensions Publication ID

28 August 2017

1046778920

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Fatcat ID

release_ppz7vya5pfewvojpnl53drnmru

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Fatcat

https://api.fatcat.wiki/v0/release/ppz7vya5pfewvojpnl53drnmru

24 November 2022

mapped directly with Wikidata item

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