Mechanisms and impacts of chromosomal translocations in cancers (Q38032210)

27 August 2017

title

Mechanisms and impacts of chromosomal translocations in cancers (English)

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27 August 2017

Jing H Wang

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27 August 2017

publication date

4 August 2012

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27 August 2017

published in

Frontiers of medicine

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27 August 2017

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27 August 2017

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27 August 2017

page(s)

263-274

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Cancer genetics: from Boveri and Mendel to microarrays

27 August 2017

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Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides

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The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

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An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

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An intramolecular SH3-domain interaction regulates c-Abl activity

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Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase

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Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor

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Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells

21 January 2018

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Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

21 January 2018

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Mechanisms of chromosomal translocations in B cell lymphomas

21 January 2018

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Myc translocations in B cell and plasma cell neoplasms

21 January 2018

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Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

21 January 2018

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Translocations involving c-myc and c-myc function

21 January 2018

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Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells

21 January 2018

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In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development

21 January 2018

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Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

21 January 2018

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

21 January 2018

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

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Mechanisms that promote and suppress chromosomal translocations in lymphocytes

21 January 2018

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The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers

21 January 2018

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Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations

21 January 2018

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Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures

21 January 2018

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Mechanisms of chromosomal rearrangement in the human genome

21 January 2018

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V(D)J recombination: mechanisms of initiation

21 January 2018

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Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

21 January 2018

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The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

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Evolution of the immunoglobulin heavy chain class switch recombination mechanism

21 January 2018

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

21 January 2018

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IgH class switching and translocations use a robust non-classical end-joining pathway

21 January 2018

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

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How does DNA break during chromosomal translocations?

21 January 2018

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Cryptic signals and the fidelity of V(D)J joining

21 January 2018

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V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

21 January 2018

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Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints

21 January 2018

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Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

21 January 2018

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A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

21 January 2018

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Mechanisms of B-cell lymphoma pathogenesis

21 January 2018

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Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity

21 January 2018

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Activation-induced cytidine deaminase in antibody diversification and chromosome translocation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11684-012-0215-5

AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11684-012-0215-5

AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11684-012-0215-5

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11684-012-0215-5

Mechanisms promoting translocations in editing and switching peripheral B cells

21 January 2018

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The cellular response to general and programmed DNA double strand breaks

21 January 2018

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Reflections and meditations upon complex chromosomal exchanges

21 January 2018

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Frequent chromosomal translocations induced by DNA double-strand breaks

21 January 2018

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Genetic manipulation of genomes with rare-cutting endonucleases

21 January 2018

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Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

21 January 2018

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Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells

21 January 2018

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Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes

21 January 2018

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Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

21 January 2018

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Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.

21 January 2018

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Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases

21 January 2018

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Homing endonuclease structure and function

21 January 2018

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Chromosome territories, nuclear architecture and gene regulation in mammalian cells

21 January 2018

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21 January 2018

Chromosome territories

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Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers

21 January 2018

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Comprehensive mapping of long-range interactions reveals folding principles of the human genome

21 January 2018

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Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains

21 January 2018

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Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

21 January 2018

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Interphase chromosomes undergo constrained diffusional motion in living cells

21 January 2018

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Positional stability of single double-strand breaks in mammalian cells

21 January 2018

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Spatial genome organization in the formation of chromosomal translocations

21 January 2018

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Myc dynamically and preferentially relocates to a transcription factory occupied by Igh

21 January 2018

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Induced chromosomal proximity and gene fusions in prostate cancer

21 January 2018

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Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma

21 January 2018

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Spatial organization of the mouse genome and its role in recurrent chromosomal translocations

21 January 2018

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Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements

21 January 2018

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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

21 January 2018

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

21 January 2018

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Molecular cytogenetics in haematological malignancy: current technology and future prospects

21 January 2018

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The new cytogenetics: blurring the boundaries with molecular biology

21 January 2018

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

21 January 2018

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

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ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer.

21 January 2018

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KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer

21 January 2018

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Mechanisms and consequences of chromosomal translocation

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Chromosomal translocations in childhood leukemia: natural history, mechanisms, and epidemiology

21 January 2018

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Epidemiology: clues to the pathogenesis of Burkitt lymphoma

21 January 2018

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Origins of chromosome translocations in childhood leukaemia

21 January 2018

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

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21 January 2018

12 December 2020

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

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A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

21 January 2018

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12 December 2020

Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas

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Regulation of immunoglobulin light chain isotype expression

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The retinoic acid alpha receptor gene is frequently disrupted in its 5' part in Chinese patients with acute promyelocytic leukemia

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DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes

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12 December 2020

Cancer. Proximity matters

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The nuclear topography of ABL, BCR, PML, and RARalpha genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation

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Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

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N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl

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Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma

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Clinical implications of next-generation sequencing for cancer medicine.

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I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila

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Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

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Some current problems of cancer cytogenetics

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Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential

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Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3

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Increased chromosome mobility facilitates homology search during recombination

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The 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype

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A brief survey of aberration origin theories

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12 December 2020

Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation.

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Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

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12 December 2020

10.1007/S11684-012-0215-5

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1007441590

0 references

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