The mechanism and regulation of chromosomal V(D)J recombination (Q34619795)

3 August 2017

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title

The mechanism and regulation of chromosomal V(D)J recombination (English)

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3 August 2017

Craig H Bassing

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3 August 2017

Wojciech Swat

series ordinal

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3 August 2017

Frederick W Alt

series ordinal

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3 August 2017

language of work or name

English

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publication date

1 April 2002

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3 August 2017

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3 August 2017

volume

109 Suppl

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3 August 2017

page(s)

S45-55

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

3 August 2017

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

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DNA end-joining catalyzed by human cell-free extracts

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Going the distance: a current view of enhancer action

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Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

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The SCID mouse mutant: definition, characterization, and potential uses

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Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

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Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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DNA repair: how Ku makes ends meet.

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Initiation of V(D)J recombination in vitro obeying the 12/23 rule

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DNA double strand break repair and chromosomal translocation: lessons from animal models

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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7 January 2021

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

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7 January 2021

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion

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7 January 2021

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

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7 January 2021

Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

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7 January 2021

Regulation of immunoglobulin light chain isotype expression

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7 January 2021

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

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7 January 2021

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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7 January 2021

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

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7 January 2021

Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells

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7 January 2021

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining

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7 January 2021

Factors and forces controlling V(D)J recombination

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7 January 2021

Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells

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7 January 2021

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

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7 January 2021

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors

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Towards an understanding of somatic hypermutation

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DNA double-strand breaks: signaling, repair and the cancer connection

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

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7 January 2021

Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

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7 January 2021

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

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Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

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7 January 2021

Developmental regulation of V(D)J recombination at the TCR alpha/delta locus.

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7 January 2021

Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

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7 January 2021

Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

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7 January 2021

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

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7 January 2021

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

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7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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7 January 2021

Ku86 is essential in human somatic cells

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7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1 reference

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7 January 2021

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

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7 January 2021

Genetic modulation of T cell receptor gene segment usage during somatic recombination

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7 January 2021

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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7 January 2021

Mechanism and control of class-switch recombination

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7 January 2021

Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination

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7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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7 January 2021

A role for histone acetylation in the developmental regulation of VDJ recombination.

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7 January 2021

RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

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7 January 2021

Rejoining of DNA by the RAG1 and RAG2 proteins

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7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

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7 January 2021

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

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7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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7 January 2021

Kappa chain monoallelic demethylation and the establishment of allelic exclusion

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7 January 2021

Asynchronous replication and allelic exclusion in the immune system

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7 January 2021

Revising B cell receptors

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7 January 2021

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7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

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7 January 2021

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

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7 January 2021

New glimpses of an old machine

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7 January 2021

Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints

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7 January 2021

Clonal selection and learning in the antibody system

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7 January 2021

Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions

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7 January 2021

The genetic and biochemical basis of Omenn syndrome

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7 January 2021

MARs of antigen receptor and co-receptor genes.

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7 January 2021

Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

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7 January 2021

RAG mutations in human B cell-negative SCID.

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7 January 2021

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

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7 January 2021

Limited effect of chromatin remodeling on D(beta)-to-J(beta) recombination in CD4+CD8+ thymocyte: implications for a new aspect in the regulation of TCR beta gene recombination.

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes.

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7 January 2021

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

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7 January 2021

Function of the TCR alpha enhancer in alphabeta and gammadelta T cells

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7 January 2021

Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion

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7 January 2021

Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments

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7 January 2021

Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro

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7 January 2021

The language of covalent histone modifications

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7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

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7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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7 January 2021

T cell receptor (TCR)-beta gene recombination: dissociation from cell cycle regulation and developmental progression during T cell ontogeny

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

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7 January 2021

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7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

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7 January 2021

Partial V(D)J recombination activity leads to Omenn syndrome

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7 January 2021

Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility.

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7 January 2021

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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7 January 2021

Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter

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7 January 2021

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900675-X

7 January 2021

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900675-X

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900675-X

7 January 2021

10.1016/S0092-8674(02)00675-X

Identifiers

DOI

1 reference

3 August 2017

1 reference