Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma. (Q38030652)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22846158%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma (English)

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9 February 2020

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9 February 2020

Boris Ratnikov

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9 February 2020

Jessica De Ingeniis

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9 February 2020

Jeffrey W Smith

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9 February 2020

Andrei L Osterman

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9 February 2020

David A Scott

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9 February 2020

publication date

1 October 2012

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Pigment Cell & Melanoma Research

9 February 2020

published in

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9 February 2020

volume

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9 February 2020

issue

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9 February 2020

page(s)

732-739

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Regulation of glycolysis and the Warburg effect by estrogen-related receptors

9 February 2020

cites work

1 reference

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

6 September 2017

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Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

6 September 2017

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Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells

6 September 2017

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Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells

6 September 2017

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

6 September 2017

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

6 September 2017

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

6 September 2017

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

6 September 2017

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

6 September 2017

1 reference

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Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

6 September 2017

1 reference

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PHGDH amplification and altered glucose metabolism in human melanoma

6 September 2017

1 reference

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

6 September 2017

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

6 September 2017

1 reference

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

6 September 2017

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

6 September 2017

1 reference

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Otto Warburg's contributions to current concepts of cancer metabolism

6 September 2017

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Exome sequencing identifies GRIN2A as frequently mutated in melanoma

6 September 2017

1 reference

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Hallmarks of Cancer: The Next Generation

6 September 2017

1 reference

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Mutant IDH1 Confers an in Vivo Growth in a Melanoma Cell Line with BRAF Mutation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

6 September 2017

1 reference

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Quiescent fibroblasts exhibit high metabolic activity.

6 September 2017

1 reference

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IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.

6 September 2017

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

6 September 2017

1 reference

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

6 September 2017

1 reference

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

6 September 2017

1 reference

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Cancer morphogenesis: role of mitochondrial failure.

6 September 2017

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Targeting aspartate aminotransferase in breast cancer

6 September 2017

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An integrated genomic analysis of human glioblastoma multiforme

6 September 2017

1 reference

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

6 September 2017

1 reference

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Central carbon metabolism in the progression of mammary carcinoma

6 September 2017

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Role of nuclear medicine in the management of cutaneous malignant melanoma.

6 September 2017

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Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells.

6 September 2017

1 reference

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Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Comparative metabolomics of breast cancer.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639292

31 August 2018

Identifiers

DOI

10.1111/PCMR.12000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22846158%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

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9 February 2020

PubMed publication ID

22846158

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22846158%20AND%20SRC:MED&resulttype=core&format=json