Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells (Q36206219)

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English	Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells (English)

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Europe PubMed Central

PMC publication ID

12 August 2017

5

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Lynn Feun

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Europe PubMed Central

PMC publication ID

12 August 2017

author name string

Wen-Bin Tsai

1

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Europe PubMed Central

PMC publication ID

12 August 2017

Isamu Aiba

2

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Europe PubMed Central

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12 August 2017

Yan Long

3

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Europe PubMed Central

PMC publication ID

12 August 2017

Hui-Kuan Lin

4

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Europe PubMed Central

PMC publication ID

12 August 2017

Niramol Savaraj

6

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Europe PubMed Central

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12 August 2017

Macus Tien Kuo

7

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Europe PubMed Central

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12 August 2017

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publication date

29 March 2012

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Europe PubMed Central

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12 August 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

12 August 2017

72

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Europe PubMed Central

PMC publication ID

12 August 2017

10

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Europe PubMed Central

PMC publication ID

12 August 2017

2622-2633

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

1 reference

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A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

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1 October 2017

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

1 reference

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Combination of targeted therapy and immunotherapy in melanoma

1 reference

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Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

1 reference

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Proteolytic Control of the Oncoprotein Transcription Factor Myc

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433038

1 October 2017

MYC and Metastasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433038

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New phosphatidylinositol 3-kinase inhibitors for cancer

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

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Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

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Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.

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Akt inhibitors in clinical development for the treatment of cancer

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model

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Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

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Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.

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1 October 2017

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.

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Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells

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Perifosine: update on a novel Akt inhibitor.

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

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Topoisomerase I inhibitors for the treatment of brain tumors

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Arginine deiminase, a potential anti-tumor drug

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433038

1 October 2017

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433038

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HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433038

1 October 2017

The ubiquitin-specific protease USP28 is required for MYC stability

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433038

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Melanoma biology and new targeted therapy

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A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

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The life cycle of C-myc: from synthesis to degradation

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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

1 reference

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

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Genomic targets of the human c-Myc protein

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

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Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells

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Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

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Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

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2 July 2018

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22 September 2018

Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies

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Cancer genomics: from discovery science to personalized medicine

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based on heuristic

inferred from PubMed ID database lookup

Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22461507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-11-3605

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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