Otto Warburg's contributions to current concepts of cancer metabolism (Q29617601)

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29 January 2020

review article

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title

Otto Warburg's contributions to current concepts of cancer metabolism (English)

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29 January 2020

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29 January 2020

Patricia L Bounds

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language of work or name

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30 April 2017

publication date

14 April 2011

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29 January 2020

published in

Nature Reviews Cancer

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29 January 2020

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30 April 2017

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29 January 2020

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29 January 2020

page(s)

325-337

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über den Stoffwechsel der Carcinomzelle

29 January 2020

cites work

1 reference

Oxygen as a factor in photosynthesis

31 March 2020

1 reference

The cancer cell's "power plants" as promising therapeutic targets: an overview

31 March 2020

1 reference

Otto Heinrich Warburg, 1883-1970

31 March 2020

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The question of nepotism in the award of Nobel prizes: a critique of the view of Hans Krebs

31 March 2020

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In situ oxygen consumption rates of cells in V-79 multicellular spheroids during growth

31 March 2020

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Modeling of oxygen transport across tumor multicellular layers

31 March 2020

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Some Patterns of the Respiratory Pigments of Ascites Tumors of Mice

31 March 2020

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Spectroscopic evidence of metabolic control

31 March 2020

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On respiratory impairment in cancer cells

31 March 2020

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THE METABOLISM OF TUMORS IN THE BODY

31 March 2020

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Observations on the carbohydrate metabolism of tumours

31 March 2020

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Akt stimulates aerobic glycolysis in cancer cells

31 March 2020

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31 March 2020

Oncogenes come of age.

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

1 reference

An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

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Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

31 March 2020

1 reference

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma

31 March 2020

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

31 March 2020

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Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

31 March 2020

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

31 March 2020

1 reference

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

31 March 2020

1 reference

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

31 March 2020

1 reference

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

31 March 2020

1 reference

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

31 March 2020

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

31 March 2020

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

31 March 2020

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

31 March 2020

1 reference

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

31 March 2020

1 reference

mtDNA mutations increase tumorigenicity in prostate cancer

31 March 2020

1 reference

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

31 March 2020

1 reference

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

31 March 2020

1 reference

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

31 March 2020

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

1 reference

Cancer cell metabolism: Warburg and beyond

31 March 2020

1 reference

HIF-1: upstream and downstream of cancer metabolism

31 March 2020

1 reference

Brick by brick: metabolism and tumor cell growth

31 March 2020

1 reference

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

31 March 2020

1 reference

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

31 March 2020

1 reference

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

31 March 2020

1 reference

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

31 March 2020

1 reference

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

31 March 2020

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

1 reference

Pyruvate kinase type M2 and its role in tumor growth and spreading

31 March 2020

1 reference

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

31 March 2020

1 reference

c-Myc target genes involved in cell growth, apoptosis, and metabolism

31 March 2020

1 reference

Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

31 March 2020

1 reference

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

31 March 2020

1 reference

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

31 March 2020

1 reference

Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.

31 March 2020

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

1 reference

Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition

31 March 2020

1 reference

Regulation of the Warburg effect in early-passage breast cancer cells.

31 March 2020

1 reference

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

31 March 2020

1 reference

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

31 March 2020

1 reference

Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer

31 March 2020

1 reference

Ras enhances Myc protein stability.

31 March 2020

1 reference

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

31 March 2020

1 reference

p53 inhibits hypoxia-inducible factor-stimulated transcription

31 March 2020

1 reference

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

1 reference

31 March 2020

1 reference

The role of p53 in glucose metabolism

31 March 2020

1 reference

p53 regulates mitochondrial respiration

31 March 2020

1 reference

Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism

31 March 2020

1 reference

Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance

31 March 2020

1 reference

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

31 March 2020

1 reference

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

31 March 2020

1 reference

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

31 March 2020

1 reference

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

31 March 2020

1 reference

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

31 March 2020

1 reference

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

31 March 2020

1 reference

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism

31 March 2020

1 reference

Glutamine synthetase immunostaining correlates with pathologic features of hepatocellular carcinoma and better survival after radiofrequency thermal ablation

31 March 2020

1 reference

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

31 March 2020

1 reference

Alternative fuel--another role for p53 in the regulation of metabolism

31 March 2020

1 reference

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

31 March 2020

1 reference

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

31 March 2020

1 reference

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

31 March 2020

1 reference

Quiescent fibroblasts exhibit high metabolic activity.

31 March 2020

1 reference

A unique glucose-dependent apoptotic pathway induced by c-Myc

31 March 2020

1 reference

Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.

31 March 2020

1 reference

31 March 2020

Autophagy and Metabolism

1 reference

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

31 March 2020

1 reference

Metabolic modulation of glioblastoma with dichloroacetate

31 March 2020

1 reference

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism

31 March 2020

1 reference

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

31 March 2020

1 reference

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production

31 March 2020

1 reference

Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation

31 March 2020

1 reference

Tumor cell metabolism: cancer's Achilles' heel

31 March 2020

1 reference

Regulation of cancer cell metabolism

31 March 2020

1 reference

Targeting metabolic transformation for cancer therapy.

31 March 2020

1 reference

Targeting aspartate aminotransferase in breast cancer

31 March 2020

1 reference

The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion

31 March 2020

1 reference

Glutaminase activities and growth rates of rat hepatomas.

31 March 2020

1 reference

12 December 2020

On respiratory impairment in cancer cells

1 reference

12 December 2020

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression

1 reference

12 December 2020

The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme

1 reference

12 December 2020

Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.

1 reference

12 December 2020

Loss of PTEN facilitates HIF-1-mediated gene expression

1 reference

12 December 2020

p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.

1 reference

12 December 2020

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

1 reference

12 December 2020

Bioenergetics and the problem of tumor growth

1 reference

12 December 2020

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production

1 reference

12 December 2020

Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase.

1 reference

12 December 2020

p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene

1 reference

12 December 2020

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Identifiers

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30 April 2017

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Dimensions Publication ID

29 January 2020

1008995827

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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