Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism (Q37983747)

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Increased baseline occupancy of D2 receptors by dopamine in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Understanding wiring and volume transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Inverse agonist properties of atypical antipsychotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The functional anatomy of basal ganglia disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Lipid raft microdomains and neurotransmitter signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Why are long-acting beta-adrenoceptor agonists long-acting?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D2 receptor dimer formation: evidence from ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine and serotonin in the striatum of the cat. Effect of lesions of the intralaminar nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine as a Prolactin (PRL) Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Identification and terminal distribution of the tubero-hypophyseal monoamine fibre systems in the rat by means of stereotaxic and microspectrofluorimetric techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Restricted collision coupling of the A2A receptor revisited: evidence for physical separation of two signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Drug-target residence time and its implications for lead optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

DAncing past the DAT at a DA synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Limbic/mesolimbic connections and the pathogenesis of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Stimulant psychosis: systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine in schizophrenia: a review and reconceptualization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Binding of "AT4 receptor" ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Influence of phasic and tonic dopamine release on receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Guanine nucleotide binding proteins mediate D2 dopamine receptor activation of a potassium channel in rat lactotrophs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The role of D1-D2 receptor hetero-dimerization in the mechanism of action of clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Distinct binding properties of the AT(1) receptor antagonist [(3)H]candesartan to intact cells and membrane preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The origin of the dopamine nerve terminals in limbic and frontal cortex. Evidence for meso-cortico dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Quantitative studies of antagonists for 5-hydroxytryptamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Pharmacological analysis of dopamine stimulation of [35S]-GTP gamma S binding via human D2short and D2long dopamine receptors expressed in recombinant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Pharmacological analysis of a dopamine D(2Short):G(alphao) fusion protein expressed in Sf9 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Distinct roles for Galpha(i)2 and Gbetagamma in signaling to DNA synthesis and Galpha(i)3 in cellular transformation by dopamine D2S receptor activation in BALB/c 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Characterization of dopaminergic compounds at hD2short, hD4.2 and hD4.7 receptors in agonist-stimulated [35S]GTPgammaS binding assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Effect of reserpine-induced depletion of synaptic dopamine on [11C]raclopride binding to D2-dopamine receptors in the monkey brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Detection of angiotensin II type 1 receptor ligands by a cell-based assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Neurobiology of dopamine in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

N-[11C]methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Receptor binding of N-(methyl-11C) clozapine in the brain of rhesus monkey studied by positron emission tomography (PET).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Involvement of basal ganglia transmitter systems in movement initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

21 January 2018

The history of clozapine

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Contribution of dead-space microdomains to tortuosity of brain extracellular space

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Signal transduction pathways modulated by the D2 subfamily of dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Agranulocytosis during treatment with chlozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Most central nervous system D2 dopamine receptors are coupled to their effectors by Go

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Expression of D2 receptor isoforms in cultured neurons reveals equipotent autoreceptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Multiple receptors for dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Ligand-selective receptor conformations revisited: the promise and the problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Determining the potency and molecular mechanism of action of insurmountable antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Mechanisms of action of atypical antipsychotic drugs: a critical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Effects of losartan vs candesartan in reducing cardiovascular events in the primary treatment of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Evidence for striatal dopamine release during a video game

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

In vivo binding behavior of dopamine receptor agonist (+)-PD 128907 and implications for the "ceiling effect" in endogenous competition studies with [(11)C]raclopride-a positron emission tomography study in Macaca mulatta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Peripheral 5-HT2-like receptors. Can they be classified with the available antagonists?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Provocative tests with psychostimulant drugs in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antagonism of long-acting beta2-adrenoceptor agonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Diversity of mechanism-based pharmacodynamic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

G protein-coupled receptor sorting to endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Absence of receptor reserve at striatal dopamine receptors regulating cholinergic neuronal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The role of serotonin in antipsychotic drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Presynaptic Dopamine in Schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

From motivation to action: functional interface between the limbic system and the motor system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Influence of dopamine on limbic inputs to the nucleus accumbens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Mechanism of agonist and antagonist binding to alpha 2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D2 receptor dimers and receptor-blocking peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The influence of G protein subtype on agonist action at D2 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Heterotrimeric G protein activation by G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Does clozapine work by blocking spikes and sparing bursts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy--a simulation study based on experimental data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antagonist-radioligand binding to D2L-receptors in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antagonist-D2S-dopamine receptor interactions in intact recombinant Chinese hamster ovary cells [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Non-competitive interaction between raclopride and spiperone on human D-receptors in intact Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Internalization of D2 dopamine receptors is clathrin-dependent and select to dendro-axonic appositions in primate prefrontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Real-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Prolactin and antipsychotic medications: mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Lipid rafts: bringing order to chaos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Limbic selectivity of clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Atypical antipsychotics: are some more atypical than others?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Mechanisms of inverse agonist action at D2 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Mechanisms of agonist action at D2 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Anatomically distinct dopamine release during anticipation and experience of peak emotion to music

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The search for novel antipsychotics: pharmacological and molecular targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Multiple Dopamine Functions at Different Time Courses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

An update of fast-off dopamine D2 atypical antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D2High receptors measured ex vivo are elevated in amphetamine-sensitized animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Brain receptors for antipsychotic drugs and dopamine: direct binding assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Antipsychotic drug doses and neuroleptic/dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

New dopamine receptor, D2(Longer), with unique TG splice site, in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine displaces [3H]domperidone from high-affinity sites of the dopamine D2 receptor, but not [3H]raclopride or [3H]spiperone in isotonic medium: Implications for human positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Psychosis pathways converge via D2high dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Anatomical substrates for glutamate-dopamine interactions: evidence for specificity of connections and extrasynaptic actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Influence of the beta-adrenergic receptor concentration on functional coupling to the adenylate cyclase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Risperidone irreversibly binds to and inactivates the h5-HT7 serotonin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Diffusion delays and unstirred layer effects at monolayer cultures of Chinese hamster ovary cells: radioligand binding, confocal microscopy, and mathematical simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Clozapine can induce high dopamine D(2) receptor occupancy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Biochemical mechanisms of drug action: what does it take for success?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

No support for regional selectivity in clozapine-treated patients: a PET study with [(11)C]raclopride and [(11)C]FLB 457.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Significant dissociation of brain and plasma kinetics with antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Residence time of receptor-ligand complexes and its effect on biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Elevation of prolactin levels by atypical antipsychotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Distinct functions of the two isoforms of dopamine D2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Ligands, their receptors and ... plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Kinetic versus allosteric mechanisms to explain insurmountable antagonism and delayed ligand dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Slow antagonist dissociation and long-lasting in vivo receptor protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Models and methods for studying insurmountable antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

New insights in insurmountable antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Site-directed mutagenesis at the human B2 receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Dopamine D2 and D4 receptor ligands: relation to antipsychotic action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Extrastriatal and striatal D(2) dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: light and electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Distinct Roles for Gαi2, Gαi3, and Gβγ in Modulation of Forskolin- or Gs-mediated cAMP Accumulation and Calcium Mobilization by Dopamine D2S Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-012-0734-2

Behavioral and radioligand binding evidence for irreversible dopamine receptor blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

21 January 2018

1 reference

12 December 2020

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1 reference

12 December 2020

The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

1 reference

12 December 2020

A dopaminergic deficit hypothesis of schizophrenia: the path to discovery

1 reference

12 December 2020

The classification of seven transmembrane receptors in recombinant expression systems

1 reference

12 December 2020

Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications.

1 reference

12 December 2020

D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade.

1 reference

12 December 2020

Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release

1 reference

12 December 2020

Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling

1 reference

12 December 2020

Comparison of the ligand binding and signaling properties of human dopamine D(2) and D(3) receptors in Chinese hamster ovary cells.

1 reference

12 December 2020

Functional coupling of the human dopamine D2 receptor with G alpha i1, G alpha i2, G alpha i3 and G alpha o G proteins: evidence for agonist regulation of G protein selectivity

1 reference

12 December 2020

Dopamine D2(High) receptors on intact cells

1 reference

12 December 2020

Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.

1 reference

12 December 2020

Relationship between receptor occupancy and response at striatal dopamine autoreceptors

1 reference

12 December 2020

Some quantitative uses of drug antagonists

1 reference

12 December 2020

Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells

1 reference

12 December 2020

Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action

1 reference

12 December 2020

Clozapine. A novel antipsychotic agent

1 reference

12 December 2020

Atypical antipsychotics: mechanism of action.

1 reference

12 December 2020

Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia

1 reference

12 December 2020

Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

1 reference

12 December 2020

A historical perspective of clozapine.

1 reference

12 December 2020

The kinetics of competitive radioligand binding predicted by the law of mass action.

1 reference

12 December 2020

Scintillation proximity assay as a high-throughput method to identify slowly dissociating nonpeptide ligand binding to the GnRH receptor

1 reference

12 December 2020

Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s).

1 reference

12 December 2020

Interactions of novel dopaminergic ligands with D-1 and D-2 dopamine receptors

1 reference

12 December 2020

The importance of drug-target residence time.

1 reference

12 December 2020

D2 dopamine receptor activation of potassium channels in identified rat lactotrophs: whole-cell and single-channel recording

1 reference

12 December 2020

Shallow agonist competition binding curves for beta-adrenergic receptors: the role of tight agonist binding

1 reference

12 December 2020

Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor.

1 reference

12 December 2020

Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding

1 reference

12 December 2020

The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals

1 reference

12 December 2020

Half a century of antipsychotics and still a central role for dopamine D2 receptors

1 reference

12 December 2020

Sequestration of the short and long isoforms of dopamine D2 receptors expressed in Chinese hamster ovary cells

1 reference

12 December 2020

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4

1 reference

12 December 2020

Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site.

1 reference

12 December 2020

Dynamic dopamine-antagonist interactions at recombinant human dopamine D(2short) receptor: dopamine-bound versus antagonist-bound receptor states.

1 reference

12 December 2020

Clozapine occupies high levels of dopamine D2 receptors

1 reference

12 December 2020

Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors

1 reference

12 December 2020

Operational models of pharmacological agonism.

1 reference

12 December 2020

Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol

1 reference

12 December 2020

Molecular properties affecting fast dissociation from the D2 receptor

1 reference

12 December 2020

5-hydroxytryptamine2A receptor inverse agonists as antipsychotics

1 reference

12 December 2020

Agonist-induced desensitization of D2 dopamine receptors in human Y-79 retinoblastoma cells

1 reference

12 December 2020

Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cel

1 reference

12 December 2020

Agonist and antagonist binding to alpha 2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry

1 reference

12 December 2020

Characterization of [3H]quinpirole binding to human dopamine D2A and D3 receptors: effects of ions and guanine nucleotides

1 reference

12 December 2020

Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents

1 reference

12 December 2020

Use of novel antipsychotic drugs

1 reference

12 December 2020

Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system

1 reference

12 December 2020

Estimation of agonist dissociation constants at central presynaptic alpha-2 autoreceptors in the absence of autoinhibition

1 reference

12 December 2020

Effect of saponin and filipin on antagonist binding to AT 1 receptors in intact cells

1 reference

12 December 2020

Antipsychotic-induced alterations in D2 dopamine receptor interacting proteins within the cortex

1 reference

12 December 2020

An introduction to PET and SPECT neuroreceptor quantification models.

1 reference

12 December 2020

The role of binding kinetics in therapeutically useful drug action

1 reference

12 December 2020

Association of candesartan vs losartan with all-cause mortality in patients with heart failure

1 reference

12 December 2020

Coordinated expression of dopamine receptors in neostriatal medium spiny neurons

1 reference

12 December 2020

Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain

1 reference

12 December 2020

Multiple receptors coupled to adenylate cyclase regulate Na-H exchange independent of cAMP.

1 reference

12 December 2020

Locking of hormone in the beta-adrenergic receptor by attack on a sulfhydryl in an associated component

1 reference

12 December 2020

The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group

1 reference

12 December 2020

Inactivation of beta-adrenergic receptors by N-ethylmaleimide in S49 lymphoma cells. Agonist induction of functional receptor heterogeneity

1 reference

12 December 2020

Visualization of antipsychotic drug binding to living mesolimbic neurons reveals D2 receptor, acidotropic, and lipophilic components

1 reference

12 December 2020

Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.

1 reference

12 December 2020

Therapeutic receptor-blocking concentrations of neuroleptics.

1 reference

12 December 2020

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model

1 reference

12 December 2020

PET examination of central D2 dopamine receptor occupancy in relation to extrapyramidal syndromes in patients being treated with neuroleptic drugs

1 reference

12 December 2020

Quantitation of the guanine nucleotide binding regulatory protein Gs in S49 cell membranes using antipeptide antibodies to alpha s.

1 reference

12 December 2020

Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia

1 reference

12 December 2020

Haloperidol increases prolactin release and cyclic AMP formation in vitro: inverse agonism at dopamine D2 receptors?

1 reference

12 December 2020

Endothelin ET(B) receptors show different binding profiles in intact cells and cell membrane preparations

1 reference

12 December 2020

Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets

1 reference

12 December 2020

The dissociation rate of unlabelled dopamine antagonists and agonists from the dopamine-D2 receptor, application of an original filter method

1 reference

12 December 2020

Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s)

1 reference

12 December 2020

Atypicality of atypical antipsychotics

1 reference

12 December 2020

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

1 reference

12 December 2020

Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions

1 reference

12 December 2020

Dopamine and serotonin receptors: amino acid sequences, and clinical role in neuroleptic parkinsonism

1 reference

12 December 2020

Mechanistic differences of various AT1-receptor blockers in isolated vessels of different origin

1 reference

12 December 2020

The assessment of antagonist potency under conditions of transient response kinetics

1 reference

12 December 2020

Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: effects of chronic treatment with typical and atypical antipsychotic drugs

1 reference

12 December 2020

Dopamine receptor binding on intact cells. Absence of a high-affinity agonist-receptor binding state

1 reference

12 December 2020

The dopamine D2 receptor: two molecular forms generated by alternative splicing

1 reference

12 December 2020

Recombinant aequorin as tool for monitoring calcium concentration in subcellular compartments.

1 reference

12 December 2020

The advantage of using positron emission tomography in drug research

1 reference

12 December 2020

Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification

1 reference

12 December 2020

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

12 December 2020

Clozapine in treatment-resistant schizophrenics

1 reference

12 December 2020

Comparison of withdrawal of typical and atypical antipsychotic drugs: a case study

1 reference

12 December 2020