Models and methods for studying insurmountable antagonism (Q34987534)

5 August 2017

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title

Models and methods for studying insurmountable antagonism (English)

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5 August 2017

Georges Vauquelin

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5 August 2017

Isabelle Van Liefde

series ordinal

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5 August 2017

Patrick Vanderheyden

series ordinal

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5 August 2017

publication date

1 November 2002

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Trends in Pharmacological Sciences

5 August 2017

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

514-518

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Quantitative studies of antagonists for 5-hydroxytryptamine

5 August 2017

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A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism

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7 January 2021

Insurmountable AT(1) receptor antagonism: the need for different antagonist binding states of the receptor

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Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding

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A paradox: the 5-HT2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf. Allosteric regulation of 5-HT2-receptors

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Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants.

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Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

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Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model

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Hoe 140 and pseudo-irreversible antagonism in the rat vas deferens in vitro

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Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A

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The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis

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Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors

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Modelling of promiscuous receptor-Gi/Gs-protein coupling and effector response

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7 January 2021

The assessment of antagonist potency under conditions of transient response kinetics

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7 January 2021

Dynamic mechanisms of non-classical antagonism by competitive AT(1) receptor antagonists

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7 January 2021

The classification of 5-hydroxytryptamine receptors

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7 January 2021

Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle

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7 January 2021

Regulation of sensitivity to 5-hydroxytryptamine in pulmonary supernumerary but not conventional arteries by a 5-HT(1D)-like receptor

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7 January 2021

Insurmountable AT1 receptor antagonism: message in a model?

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7 January 2021

Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladder

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7 January 2021

Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors

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7 January 2021

Reversible and syntopic interaction between angiotensin receptor antagonists on Chinese hamster ovary cells expressing human angiotensin II type 1 receptors

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7 January 2021

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7 January 2021

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Identifiers

DOI

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5 August 2017

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