Mechanisms of granule-dependent killing (Q36988144)

17 August 2017

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title

Mechanisms of granule-dependent killing (English)

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17 August 2017

Cullen SP

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17 August 2017

Martin SJ

series ordinal

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17 August 2017

publication date

2 November 2007

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Cell Death & Differentiation

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

251-262

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Programmed cell death in animal development

17 August 2017

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Decoding the patterns of self and nonself by the innate immune system

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Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.

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Endocytosing the death sentence

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What does it take to make a natural killer?

21 January 2018

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Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells

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Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets

21 January 2018

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Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

21 January 2018

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

21 January 2018

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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

21 January 2018

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Analysis of the lysosomal storage disease Chediak-Higashi syndrome

21 January 2018

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

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Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

21 January 2018

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

21 January 2018

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Cutting edge: differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions

21 January 2018

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Centrosome polarization delivers secretory granules to the immunological synapse.

21 January 2018

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Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner

21 January 2018

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Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

21 January 2018

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Perforin and the granule exocytosis cytotoxicity pathway

21 January 2018

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Perforin-mediated target-cell death and immune homeostasis

21 January 2018

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Decreased tumor surveillance in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The role of cytotoxicity in lymphocyte homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Regulatory T cells, tumour immunity and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Activated CD4+CD25+ T cells selectively kill B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Functional size of complement and perforin pores compared by confocal laser scanning microscopy and fluorescence microphotolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Lymphocyte-mediated cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The orphan granzymes of humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme M mediates a novel form of perforin-dependent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Human and murine granzyme B exhibit divergent substrate preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Serial killers: ordering caspase activation events in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A central role for Bid in granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B-mediated apoptosis--the elephant and the blind men?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The major human and mouse granzymes are structurally and functionally divergent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cell death induced by granzyme C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Immune function in mice lacking the perforin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Functional analysis of granzyme M and its role in immunity to infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Delivering the kiss of death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

How do cytotoxic lymphocytes kill their targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

Biology of natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Processing and activation of CMH-1 by granzyme B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402244

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402244

1 reference

Dimensions Publication ID

17 August 2017

1031772310

0 references

Fatcat ID

release_lqbcgc4yj5e4lg6fxdjebg5shq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lqbcgc4yj5e4lg6fxdjebg5shq

24 November 2022

mapped directly with Wikidata item

1 reference