DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling (Q37697488)

22 August 2017

DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling (English)

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22 August 2017

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13 June 2020

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13 June 2020

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13 June 2020

D W Chan

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13 June 2020

W W Y Hui

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13 June 2020

L M N Hui

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13 June 2020

Y Qin

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13 June 2020

R R Liang

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13 June 2020

T H Y Leung

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13 June 2020

D Xu

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13 June 2020

K K L Chan

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13 June 2020

K-M Yao

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13 June 2020

B K Tsang

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13 June 2020

language of work or name

English

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publication date

5 September 2016

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22 August 2017

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13 June 2020

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13 June 2020

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13 June 2020

page(s)

1404-1416

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

13 June 2020

start time

5 September 2016

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April 2022 Public Data File from Crossref

copyrighted

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cites work

TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis

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Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer

23 August 2017

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Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis

23 August 2017

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FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c.

23 August 2017

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Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells

23 August 2017

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Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells

23 August 2017

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DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis

23 August 2017

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A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis

23 August 2017

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Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells

23 August 2017

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Integrated genomic analyses of ovarian carcinoma

23 August 2017

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ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor

23 August 2017

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Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

23 August 2017

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Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling

23 August 2017

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Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β

23 August 2017

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Deregulation of FoxM1b leads to tumour metastasis

23 August 2017

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Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231

23 August 2017

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Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling

23 August 2017

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FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution.

23 August 2017

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Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development.

23 August 2017

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The regulation of TGFbeta signal transduction

23 August 2017

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Overexpression of FOXG1 contributes to TGF-beta resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

23 August 2017

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Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons

23 August 2017

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FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells

23 August 2017

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Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis

23 August 2017

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Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells

23 August 2017

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Dlx transcription factors promote migration through repression of axon and dendrite growth

23 August 2017

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A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibroblast growth factor-2

23 August 2017

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A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment

23 August 2017

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FoxM1: at the crossroads of ageing and cancer

23 August 2017

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Transforming growth factor-beta in cancer and metastasis

23 August 2017

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Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

23 August 2017

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TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

23 August 2017

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Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy

23 August 2017

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The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature

23 August 2017

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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

23 August 2017

1 reference

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Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells

23 August 2017

1 reference

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Transcription factors in liver development, differentiation, and regeneration

23 August 2017

1 reference

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Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons

23 August 2017

1 reference

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Multiple functions of Dlx genes

23 August 2017

1 reference

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

23 August 2017

1 reference

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Id-1, a protein repressed by miR-29b, facilitates the TGFβ1-induced epithelial-mesenchymal transition in human ovarian cancer cells

23 August 2017

1 reference

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PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis

6 September 2017

1 reference

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FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

FOXM1: From cancer initiation to progression and treatment.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

FoxM1: a master regulator of tumor metastasis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Search for basonuclin target genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Critical involvement of ILK in TGFbeta1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

cAMP induced modifications of HOX D gene expression in prostate cells allow the identification of a chromosomal area involved in vivo with neuroendocrine differentiation of human advanced prostate cancers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Defining specificity of transcription factor regulatory activities.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Physiological implications of DLX homeoproteins in enamel formation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348575

1 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.307

TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2016.307

Identification of transcription factor binding sites in the human genome sequence

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2016.307

31 March 2020

Identifiers

DOI

10.1038/ONC.2016.307

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27593933%20AND%20SRC:MED&resulttype=core&format=json

release_qgijxu5gqrfn5aywvyzug37a74

13 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qgijxu5gqrfn5aywvyzug37a74

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27593933%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

27593933

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27593933%20AND%20SRC:MED&resulttype=core&format=json