Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis (Q24613046)

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Xia Lin

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Wen-Tai Chiu

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Yao-Hui Chen

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Guanzhen Yu

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Mingguang Liu

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Raymond Sawaya

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Mien-Chie Hung

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Suyun Huang

Journal of Clinical Investigation

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language of work or name

English

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publication date

February 2014

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published in

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volume

124

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issue

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page(s)

564-79

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cites work

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FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

7 April 2017

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FOXM1 confers acquired cisplatin resistance in breast cancer cells

7 April 2017

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Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling

7 April 2017

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FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

7 April 2017

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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

7 April 2017

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Nuclear targeting of transforming growth factor-beta-activated Smad complexes

7 April 2017

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A Poised Chromatin Platform for TGF-β Access to Master Regulators

7 April 2017

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Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis

7 April 2017

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7 April 2017

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Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

7 April 2017

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Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe

7 April 2017

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FoxM1 is required for execution of the mitotic programme and chromosome stability

7 April 2017

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A Smad transcriptional corepressor

7 April 2017

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The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer

7 April 2017

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The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature

7 April 2017

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Specificity and versatility in tgf-beta signaling through Smads

7 April 2017

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A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion.

7 April 2017

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FoxM1 regulates mammary luminal cell fate

27 September 2017

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Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway

27 September 2017

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Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.

27 September 2017

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Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)

27 September 2017

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Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities

27 September 2017

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Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models

27 September 2017

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Deregulation of FoxM1b leads to tumour metastasis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

FoxM1 mediates resistance to herceptin and paclitaxel.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

TGFbeta signalling: a complex web in cancer progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

The regulation of TGFbeta signal transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Ski and SnoN, potent negative regulators of TGF-beta signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Signaling cross-talk between TGF-beta/BMP and other pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Snail and slug play distinct roles during breast carcinoma progression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904622

Prognostic significance of TGFbeta-1 and pSmad2/3 in breast cancer patients with T1-2,N0 tumours

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24382352

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DEDD negatively regulates transforming growth factor-beta1 signaling by interacting with Smad3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24382352