Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. (Q37632922)

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29 February 2020

title

Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB (English)

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29 February 2020

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29 February 2020

Alfred D Kinana

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29 February 2020

Hiroshi Nikaido

series ordinal

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29 February 2020

language of work or name

English

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publication date

11 November 2013

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29 February 2020

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29 February 2020

volume

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29 February 2020

issue

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29 February 2020

page(s)

8342-8351

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Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution

29 February 2020

cites work

1 reference

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Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.

23 August 2017

1 reference

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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

23 August 2017

1 reference

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Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

23 August 2017

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Lactose permease and the alternating access mechanism

23 August 2017

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Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels

23 August 2017

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Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

23 August 2017

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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

23 August 2017

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Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

23 August 2017

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The structure of the efflux pump AcrB in complex with bile acid

23 August 2017

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Dissociation of minor groove binders from DNA: insights from metadynamics simulations

23 August 2017

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Well-Tempered Metadynamics: A Smoothly Converging and Tunable Free-Energy Method

23 August 2017

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Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist

23 August 2017

1 reference

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Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

23 August 2017

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Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

23 August 2017

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A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

23 August 2017

1 reference

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Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

23 August 2017

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Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

23 August 2017

1 reference

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Escaping free-energy minima

23 August 2017

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

23 August 2017

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Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

23 August 2017

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Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization

23 August 2017

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Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli

23 August 2017

1 reference

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Multidrug efflux pumps of gram-negative bacteria

23 August 2017

1 reference

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VMD: visual molecular dynamics

23 August 2017

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Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins

23 August 2017

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RND efflux pumps: structural information translated into function and inhibition mechanisms.

23 August 2017

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The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria

6 September 2017

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Molecular motions in drug design: the coming age of the metadynamics method

6 September 2017

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Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

6 September 2017

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Entry into and release of solvents by Escherichia coli in an organic-aqueous two-liquid-phase system and substrate specificity of the AcrAB-TolC solvent-extruding pump

6 September 2017

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Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli

14 September 2017

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Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism

14 September 2017

1 reference

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Substrate path in the AcrB multidrug efflux pump of Escherichia coli.

14 September 2017

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Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria

28 September 2017

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Outer membranes of gram-negative bacteria are permeable to steroid probes

25 June 2018

1 reference

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Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

25 June 2018

1 reference

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Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism

1 September 2018

1 reference

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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

1 September 2018

1 reference

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Behaviour of small solutes and large drugs in a lipid bilayer from computer simulations

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951271

The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3951271

Communication between multiple drug binding sites on P-glycoprotein

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24205856

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI401303V

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24205856%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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29 February 2020

PubMed publication ID

24205856

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24205856%20AND%20SRC:MED&resulttype=core&format=json