Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. (Q54457560)

30 May 2018

title

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. (English)

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30 May 2018

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30 May 2018

Eiki Yamashita

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30 May 2018

author name string

Ryosuke Nakashima

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30 May 2018

Takashi Matsumoto

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30 May 2018

Akihito Yamaguchi

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30 May 2018

language of work or name

English

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publication date

16 August 2006

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30 May 2018

published in

Nature

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30 May 2018

volume

443

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30 May 2018

issue

7108

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30 May 2018

page(s)

173-179

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30 May 2018

Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coli

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Analysis of a complete library of putative drug transporter genes in Escherichia coli

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AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

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Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

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How do exported proteins and antibiotics bypass the periplasm in Gram-negative bacterial cells?

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Crystal structure of bacterial multidrug efflux transporter AcrB

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Multidrug-exporting secondary transporters

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Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport

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Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

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Conformational flexibility in the multidrug efflux system protein AcrA.

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Structure of the periplasmic component of a bacterial drug efflux pump

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Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.

21 January 2018

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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

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On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

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Structural mechanisms of QacR induction and multidrug recognition

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Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors

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Interactions of the QacR multidrug-binding protein with structurally diverse ligands: implications for the evolution of the binding pocket.

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Aromatic-aromatic interaction: a mechanism of protein structure stabilization

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Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa

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Structure and mechanism of the lactose permease of Escherichia coli

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Processing of X-ray diffraction data collected in oscillation mode

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[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

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Improved methods for building protein models in electron density maps and the location of errors in these models

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LAFIRE: software for automating the refinement process of protein-structure analysis.

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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Efficient anisotropic refinement of macromolecular structures using FFT

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05076

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05076

Raster3D: photorealistic molecular graphics

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05076

Detection, delineation, measurement and display of cavities in macromolecular structures

21 January 2018

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Software for handling macromolecular envelopes

21 January 2018

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Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

21 January 2018

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7 January 2021

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants

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7 January 2021

Active efflux of bile salts by Escherichia coli

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7 January 2021

Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

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7 January 2021

Identifiers

DOI

10.1038/NATURE05076

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30 May 2018

Dimensions Publication ID

1040864737

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30 May 2018