Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation (Q37237654)

19 August 2017

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation (English)

1 reference

19 August 2017

Alexandre R Gingras

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Dorit Hanein

1 reference

19 August 2017

Benjamin T Goult

1 reference

19 August 2017

Xiao-Ping Xu

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19 August 2017

Mark Swift

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19 August 2017

Bipin Patel

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19 August 2017

Neil Bate

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19 August 2017

Petra M Kopp

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19 August 2017

Igor L Barsukov

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19 August 2017

David R Critchley

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19 August 2017

Niels Volkmann

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19 August 2017

30 May 2013

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Journal of Structural Biology

19 August 2017

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19 August 2017

184

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19 August 2017

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19 August 2017

21-32

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describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3799832/fullTextXML

inferred from PubMed Central ID database lookup

cites work

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

1 reference

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A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

6 September 2017

1 reference

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Subcellular localization of talin is regulated by inter-domain interactions

6 September 2017

1 reference

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Molecular mechanism of inside-out integrin regulation

6 September 2017

1 reference

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New insights into vinculin function and regulation

6 September 2017

1 reference

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The tail of integrin activation

6 September 2017

1 reference

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Structural diversity in integrin/talin interactions

6 September 2017

1 reference

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Nanoscale architecture of integrin-based cell adhesions

6 September 2017

1 reference

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The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

6 September 2017

1 reference

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Vinculin, an adapter protein in control of cell adhesion signalling

6 September 2017

1 reference

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Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

6 September 2017

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Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

6 September 2017

1 reference

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The domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site

6 September 2017

1 reference

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The final steps of integrin activation: the end game

6 September 2017

1 reference

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Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

6 September 2017

1 reference

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The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

6 September 2017

1 reference

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The tail of integrins, talin, and kindlins

6 September 2017

1 reference

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Biochemical and structural properties of the integrin-associated cytoskeletal protein talin

6 September 2017

1 reference

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The Structure of an Interdomain Complex That Regulates Talin Activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Stretching single talin rod molecules activates vinculin binding

6 September 2017

1 reference

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Structural Determinants of Integrin Binding to the Talin Rod

6 September 2017

1 reference

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RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

6 September 2017

1 reference

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Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3

6 September 2017

1 reference

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The structure of the C-terminal actin-binding domain of talin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Vinculin controls focal adhesion formation by direct interactions with talin and actin.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Structural basis of integrin activation by talin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

SPARX, a new environment for Cryo-EM image processing

6 September 2017

1 reference

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The structure and regulation of vinculin.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Structural and dynamic characterization of a vinculin binding site in the talin rod

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Talin phosphorylation sites mapped by mass spectrometry

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Global rigid body modeling of macromolecular complexes against small-angle scattering data

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

The CCPN data model for NMR spectroscopy: development of a software pipeline

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

UCSF Chimera--a visualization system for exploratory research and analysis

6 September 2017

1 reference

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Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Determination of domain structure of proteins from X-ray solution scattering

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

ERM-Merlin and EBP50 protein families in plasma membrane organization and function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

EMAN: semiautomated software for high-resolution single-particle reconstructions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

1H, 13C and 15N chemical shift referencing in biomolecular NMR

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Native talin is a dumbbell-shaped homodimer when it interacts with actin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Properties of talin from chicken gizzard smooth muscle.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Structural basis for the autoinhibition of talin in regulating integrin activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Three-dimensional structure of vinculin bound to actin filaments

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Docking of atomic models into reconstructions from electron microscopy

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Quantitative fitting of atomic models into observed densities derived by electron microscopy.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

Method for forming two-dimensional paracrystals of biological filaments on lipid monolayers

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799832

A C-terminal dimerization motif is required for focal adhesion targeting of Talin1 and the interaction of the Talin1 I/LWEQ module with F-actin

3 September 2018

1 reference

12 December 2020

Formation of 2-D paracrystals of F-actin on phospholipid layers mixed with quaternary ammonium surfactants

1 reference

12 December 2020

Talin distribution and phosphorylation in thrombin-activated platelets

1 reference

12 December 2020

Identification of functional domains in the cytoskeletal protein talin

1 reference

12 December 2020

Interaction of talin with actin: sensitive modulation of filament crosslinking activity

1 reference

12 December 2020

10.1016/J.JSB.2013.05.014

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

23726984

1 reference