Sirtuins in neurodegenerative diseases: an update on potential mechanisms. (Q37196388)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24093018%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Sirtuins in neurodegenerative diseases: an update on potential mechanisms (English)

1 reference

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26 February 2020

1 reference

1 reference

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26 February 2020

Sang-Won Min

1 reference

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26 February 2020

Peter D Sohn

series ordinal

1 reference

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26 February 2020

Seo-Hyun Cho

series ordinal

1 reference

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26 February 2020

Li Gan

series ordinal

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26 February 2020

publication date

25 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24093018%20AND%20SRC:MED&resulttype=core&format=json

Frontiers in Aging Neuroscience

26 February 2020

published in

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26 February 2020

volume

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26 February 2020

page(s)

1 reference

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Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3.

26 February 2020

cites work

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Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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6 September 2017

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Regulation of chromatin structure by poly(ADP-ribosyl)ation

6 September 2017

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6 September 2017

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SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

6 September 2017

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SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

6 September 2017

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Are sirtuins viable targets for improving healthspan and lifespan?

6 September 2017

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trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease

6 September 2017

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Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

6 September 2017

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The sirtuin SIRT6 regulates lifespan in male mice

6 September 2017

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Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

6 September 2017

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NF-κB, the first quarter-century: remarkable progress and outstanding questions

6 September 2017

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Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

6 September 2017

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Inflammation, DNA methylation and colitis-associated cancer

6 September 2017

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SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

6 September 2017

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A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction

6 September 2017

1 reference

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Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

6 September 2017

1 reference

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Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation

6 September 2017

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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

6 September 2017

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SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

6 September 2017

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

6 September 2017

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Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

6 September 2017

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Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease

6 September 2017

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6 September 2017

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Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation.

6 September 2017

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

6 September 2017

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

6 September 2017

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Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture

6 September 2017

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NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance

6 September 2017

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Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

6 September 2017

1 reference

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Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

6 September 2017

1 reference

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Acetylation of tau inhibits its degradation and contributes to tauopathy

6 September 2017

1 reference

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

6 September 2017

1 reference

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

6 September 2017

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Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.

6 September 2017

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A novel pathway regulates memory and plasticity via SIRT1 and miR-134

6 September 2017

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6 September 2017

The genetics of ageing

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Mechanisms underlying inflammation in neurodegeneration

6 September 2017

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6 September 2017

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Transcriptional control of the inflammatory response

6 September 2017

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SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.

6 September 2017

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SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

6 September 2017

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Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

6 September 2017

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Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

6 September 2017

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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

6 September 2017

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Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease

6 September 2017

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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

6 September 2017

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

6 September 2017

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Autophagy in the Pathogenesis of Disease

6 September 2017

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Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity

6 September 2017

1 reference

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Motif module map reveals enforcement of aging by continual NF-kappaB activity

6 September 2017

1 reference

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

6 September 2017

1 reference

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

6 September 2017

1 reference

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

6 September 2017

1 reference

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Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

6 September 2017

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Recovery of learning and memory is associated with chromatin remodelling

6 September 2017

1 reference

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Sirtuins in mammals: insights into their biological function

6 September 2017

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6 September 2017

The mammalian epigenome

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Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

6 September 2017

1 reference

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

6 September 2017

1 reference

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

6 September 2017

1 reference

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

6 September 2017

1 reference

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Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

6 September 2017

1 reference

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A specific amyloid-beta protein assembly in the brain impairs memory

6 September 2017

1 reference

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Roles for NF-kappaB in nerve cell survival, plasticity, and disease

6 September 2017

1 reference

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

6 September 2017

1 reference

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

6 September 2017

1 reference

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

6 September 2017

1 reference

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Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus

6 September 2017

1 reference

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

6 September 2017

1 reference

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Oxidative stress in neurodegeneration: cause or consequence?

6 September 2017

1 reference

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Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Gene regulation and DNA damage in the ageing human brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

A synaptic model of memory: long-term potentiation in the hippocampus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Activation of nuclear factor-kappa B signalling promotes cellular senescence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

NF-κB inhibition delays DNA damage-induced senescence and aging in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

100 years of Lewy pathology

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Reversal of aging by NFkappaB blockade

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3782645

3 September 2018

Identifiers

DOI

10.3389/FNAGI.2013.00053

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24093018%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24093018%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

24093018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24093018%20AND%20SRC:MED&resulttype=core&format=json