Deciphering the mechanism underlying late-onset Alzheimer disease (Q38062817)

28 August 2017

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title

Deciphering the mechanism underlying late-onset Alzheimer disease (English)

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28 August 2017

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Irene Knuesel

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28 August 2017

Dimitrije Krstic

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28 August 2017

language of work or name

English

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publication date

27 November 2012

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28 August 2017

published in

Nature Reviews Neurology

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

25-34

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Global prevalence of dementia: a Delphi consensus study

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Neuropathological alterations in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Reimagining Alzheimer's disease--an age-based hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Local neuroinflammation and the progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

A meta-analysis of cytokines in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Systemic inflammation and disease progression in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Extrusion of misfolded and aggregated proteins--a protective strategy of aging neurons?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Co-localization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Mitochondrial degeneration in dystrophic neurites of senile plaques may lead to extracellular deposition of fine filaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Aged Non-Human Primates: An Animal Model of Age-Associated Neurodegenerative Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Immunohistochemical localization of beta-amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Inflammatory proteins in plasma and the risk of dementia: the rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Association between dementia and infectious disease: evidence from a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Aging and Alzheimer's disease: lessons from the Nun Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Inflammatory changes parallel the early stages of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Depression and the risk of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

A meta-analysis of cytokines in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Sickness behavior, its mechanisms and significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Influence of continuous infusion of interleukin-1beta on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Microglia activation in sepsis: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Gene regulation and DNA damage in the ageing human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Immune and behavioral consequences of microglial reactivity in the aged brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Peripheral infection and aging interact to impair hippocampal memory consolidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

The role of microglia in amyloid clearance from the AD brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Occurrence of HLA-DR reactive microglia in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Neuroinflammation in Alzheimer's disease wanes with age

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Accumulation of tau induced in neurites by microglial proinflammatory mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Allergy influences the inflammatory status of the brain and enhances tau-phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Tau phosphorylation in neuronal cell function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Defective brain microtubule assembly in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Axonal transport and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Expression of amyloid precursor protein after rat traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Amyloid precursor protein is trafficked and secreted via synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex and hippocampal formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Caspase activation precedes and leads to tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Autophagy failure in Alzheimer's disease--locating the primary defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Plasma Abeta42 correlates positively with increased body fat in healthy individuals.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Gene-expression profile of the ageing brain in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Review: microglia of the aged brain: primed to be activated and resistant to regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

Cytochrome c release and caspase activation in traumatic axonal injury

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.236

31 March 2020

12 December 2020

The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis

1 reference

12 December 2020

Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

1 reference

12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex

1 reference

12 December 2020

In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic.

1 reference

12 December 2020

Immunolocalization of the amyloid precursor protein within the senile plaque.

1 reference

12 December 2020

Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration

1 reference

12 December 2020

10.1038/NRNEUROL.2012.236

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1042630940

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