DNA polymerases in adaptive immunity (Q37109944)

18 August 2017

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title

DNA polymerases in adaptive immunity (English)

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18 August 2017

Claude-Agnès Reynaud

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18 August 2017

Jean-Claude Weill

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18 August 2017

publication date

14 March 2008

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Nature Reviews Immunology

18 August 2017

published in

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

302-312

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Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination

18 August 2017

cites work

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Evidence that the long murine terminal deoxynucleotidyltransferase isoform plays no role in the control of V(D)J junctional diversity.

21 January 2018

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21 January 2018

Marginal-zone B cells

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Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice

21 January 2018

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DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination

21 January 2018

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Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line

21 January 2018

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SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness

21 January 2018

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Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations

21 January 2018

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Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

21 January 2018

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Somatic generation of antibody diversity

21 January 2018

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Clonal selection and learning in the antibody system

31 March 2020

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Rearrangement/hypermutation/gene conversion: when, where and why?

31 March 2020

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The expanding polymerase universe

31 March 2020

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Eukaryotic DNA polymerases: proposal for a revised nomenclature.

31 March 2020

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Eukaryotic DNA Polymerases

31 March 2020

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Specialized DNA polymerases, cellular survival, and the genesis of mutations

31 March 2020

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V(D)J recombination: RAG proteins, repair factors, and regulation

31 March 2020

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Cernunnos-XLF, a recently identified non-homologous end-joining factor required for the development of the immune system.

31 March 2020

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Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

31 March 2020

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A biochemically defined system for mammalian nonhomologous DNA end joining

31 March 2020

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Mammalian DNA beta-polymerase in base excision repair of alkylation damage.

31 March 2020

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Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway

31 March 2020

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Two novel human and mouse DNA polymerases of the polX family

31 March 2020

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DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells

31 March 2020

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DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis

31 March 2020

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Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

31 March 2020

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DNA joint dependence of pol X family polymerase action in nonhomologous end joining

31 March 2020

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A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

31 March 2020

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Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo

31 March 2020

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Distinct and opposite diversifying activities of terminal transferase splice variants

31 March 2020

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

31 March 2020

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

31 March 2020

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Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

31 March 2020

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Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

31 March 2020

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The structural repertoire of the human V kappa domain

31 March 2020

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31 March 2020

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Variability in the Lambda Light Chain Sequences of Mouse Antibody

31 March 2020

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Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region

31 March 2020

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IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

31 March 2020

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Somatic mutation of immunoglobulin light-chain variable-region genes

31 March 2020

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Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

31 March 2020

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Origin of Antibody Variation

31 March 2020

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

31 March 2020

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

31 March 2020

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

31 March 2020

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Molecular mechanisms of antibody somatic hypermutation.

31 March 2020

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Mismatch repair and immunoglobulin gene hypermutation: did we learn something?

31 March 2020

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AID and mismatch repair in antibody diversification

31 March 2020

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Somatic hypermutation: subverted DNA repair

31 March 2020

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Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

31 March 2020

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Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

31 March 2020

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Error-prone repair DNA polymerases in prokaryotes and eukaryotes

31 March 2020

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Suffering in silence: the tolerance of DNA damage

31 March 2020

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Lesion bypass activities of human DNA polymerase mu.

31 March 2020

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8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

31 March 2020

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High-efficiency bypass of DNA damage by human DNA polymerase Q

31 March 2020

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

31 March 2020

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hRAD30 mutations in the variant form of xeroderma pigmentosum

31 March 2020

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

31 March 2020

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DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

31 March 2020

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Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse

31 March 2020

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Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

31 March 2020

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Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.

31 March 2020

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Error rate and specificity of human and murine DNA polymerase eta

31 March 2020

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Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

31 March 2020

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Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

31 March 2020

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Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

31 March 2020

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The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene.

31 March 2020

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DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

31 March 2020

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Deoxycytidyl transferase activity of yeast REV1 protein

31 March 2020

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Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion

31 March 2020

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Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

31 March 2020

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The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

31 March 2020

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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

31 March 2020

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

31 March 2020

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Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.

31 March 2020

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Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.

31 March 2020

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Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.

31 March 2020

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The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.

31 March 2020

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

31 March 2020

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Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese

31 March 2020

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TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

31 March 2020

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Induction of somatic mutation in a human B cell line in vitro

31 March 2020

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AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

31 March 2020

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Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias

31 March 2020

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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

31 March 2020

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129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

31 March 2020

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Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines

31 March 2020

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The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

31 March 2020

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Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes

31 March 2020

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DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes

31 March 2020

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DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

31 March 2020

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

31 March 2020

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PCNA binding through a conserved motif

31 March 2020

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

31 March 2020

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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

31 March 2020

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PCNA, the maestro of the replication fork

31 March 2020

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

31 March 2020

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

31 March 2020

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

31 March 2020

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A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

31 March 2020

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Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

31 March 2020

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Strand-biased spreading of mutations during somatic hypermutation

31 March 2020

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Quantitative measurement of translesion replication in human cells: evidence for bypass of abasic sites by a replicative DNA polymerase

31 March 2020

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Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions

31 March 2020

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Light chain gene conversion continues at high rate in an ALV-induced cell line.

31 March 2020

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

31 March 2020

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

31 March 2020

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Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

31 March 2020

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Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis

31 March 2020

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What role for AID: mutator, or assembler of the immunoglobulin mutasome?

31 March 2020

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Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination

31 March 2020

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Role of mutator alleles in adaptive evolution.

31 March 2020

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Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

31 March 2020

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A role for PCNA ubiquitination in immunoglobulin hypermutation

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2281

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18 August 2017

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