What role for AID: mutator, or assembler of the immunoglobulin mutasome? (Q35164207)

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5 November 2019

review article

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title

What role for AID: mutator, or assembler of the immunoglobulin mutasome? (English)

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5 November 2019

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5 November 2019

Claude-Agnès Reynaud

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5 November 2019

Ahmad Faili

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5 November 2019

Jean-Claude Weill

series ordinal

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5 November 2019

language of work or name

English

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publication date

1 July 2003

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5 November 2019

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5 November 2019

volume

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5 November 2019

issue

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5 November 2019

page(s)

631-638

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Factors and forces controlling V(D)J recombination

5 November 2019

cites work

1 reference

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The dynamic nature of the antibody repertoire

21 January 2018

1 reference

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Rearrangement/hypermutation/gene conversion: when, where and why?

21 January 2018

1 reference

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

1 reference

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

21 January 2018

1 reference

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

21 January 2018

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

21 January 2018

1 reference

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The AID enzyme induces class switch recombination in fibroblasts

21 January 2018

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Emerging links between hypermutation of antibody genes and DNA polymerases

21 January 2018

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21 January 2018

Marginal-zone B cells

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Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity

21 January 2018

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

21 January 2018

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Mechanism and control of class-switch recombination

21 January 2018

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Ig gene hypermutation: a mechanism is due.

21 January 2018

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

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Molecular mechanisms of apolipoprotein B mRNA editing

21 January 2018

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An immunoglobulin mutator that targets G.C base pairs

21 January 2018

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

21 January 2018

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Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

21 January 2018

1 reference

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Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

21 January 2018

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Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

21 January 2018

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Induction of somatic mutation in a human B cell line in vitro

21 January 2018

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TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

21 January 2018

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

21 January 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

1 reference

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

1 reference

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

1 reference

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

21 January 2018

1 reference

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Uracil in DNA--occurrence, consequences and repair

21 January 2018

1 reference

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Low fidelity DNA synthesis by human DNA polymerase-eta

21 January 2018

1 reference

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Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.

21 January 2018

1 reference

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

21 January 2018

1 reference

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Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.

21 January 2018

1 reference

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Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.

21 January 2018

1 reference

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Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.

21 January 2018

1 reference

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REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase

21 January 2018

1 reference

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

21 January 2018

1 reference

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hRAD30 mutations in the variant form of xeroderma pigmentosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

21 January 2018

1 reference

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A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil.

21 January 2018

1 reference

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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

21 January 2018

1 reference

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Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

21 January 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

21 January 2018

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Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

21 January 2018

1 reference

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Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

21 January 2018

1 reference

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

21 January 2018

1 reference

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Mismatch repair and immunoglobulin gene hypermutation: did we learn something?

21 January 2018

1 reference

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Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice.

21 January 2018

1 reference

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

21 January 2018

1 reference

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Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

21 January 2018

1 reference

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Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

21 January 2018

1 reference

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Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases.

21 January 2018

1 reference

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Mutation in the Mismatch Repair Gene Msh6 Causes Cancer Susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Somatic hypermutation in the heavy chain locus correlates with transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Increased transcription levels induce higher mutation rates in a hypermutating cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Both DNA strands of antibody genes are hypermutation targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Somatic hypermutation of the AID transgene in B and non-B cells

21 January 2018

1 reference

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

21 January 2018

1 reference

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Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs

21 January 2018

1 reference

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Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Processing of switch transcripts is required for targeting of antibody class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

21 January 2018

1 reference

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RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination

21 January 2018

1 reference

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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

21 January 2018

1 reference

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Mechanisms of chromosomal translocations in B cell lymphomas

21 January 2018

1 reference

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DNA sequences at immunoglobulin switch region recombination sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

1 reference

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Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

21 January 2018

1 reference

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

1 reference

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High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia

21 January 2018

1 reference

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

21 January 2018

1 reference

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Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

AID and mismatch repair in antibody diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

7 January 2021

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

7 January 2021

Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

7 January 2021

The influence of transcriptional orientation on endogenous switch region function

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-631

7 January 2021

Identifiers

DOI

10.1038/NI0703-631

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12830138%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12830138%20AND%20SRC:MED&resulttype=core&format=json