Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells (Q36979845)

17 August 2017

Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells (English)

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chronic lymphocytic leukemia

17 August 2017

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1 reference

M S Gordon

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17 August 2017

R M Kato

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17 August 2017

F Lansigan

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17 August 2017

A A Thompson

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17 August 2017

R Wall

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17 August 2017

D J Rawlings

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17 August 2017

language of work or name

English

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publication date

1 May 2000

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Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

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17 August 2017

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17 August 2017

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17 August 2017

5504-5509

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Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

BLNK: a central linker protein in B cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Proliferation of B cell malignancies in all stages of differentiation upon stimulation in the 'CD40 system'.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Fate of surrogate light chains in B lineage cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The B-cell antigen receptor complex and co-receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

29 September 2017

Somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Lymphocyte activation in health and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Genes and chromosomes in chronic B-cell leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Assembly and intracellular transport of the human B cell antigen receptor complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The cellular biology of B-cell chronic lymphocytic leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Molecular biology of chronic lymphocytic leukemia

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The complexity of signaling pathways activated by the BCR.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

High-titer retroviral vectors for efficient transduction of functional genes into murine hematopoietic stem cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Molecular components of the B-cell antigen receptor complex of the IgM class

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Functional reconstitution of an immunoglobulin antigen receptor in T cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

27 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Somatic hypermutation in normal and transformed human B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

4 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25858

Trisomy 12 in B-cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization

20 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Deletion of chromosome 13 (band q14) but not trisomy 12 is a clonal event in B-chronic lymphocytic leukaemia (CLL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Cross-linking of membrane IgM on B CLL cells: dissociation between intracellular free Ca2+ mobilization and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

A negative regulatory role for Ig-alpha during B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.090087097

Mutational status of Ig V(H) genes provides clinically valuable information in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

12 December 2020

Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia

1 reference

12 December 2020

Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells

1 reference

12 December 2020

Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia

1 reference

12 December 2020

Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.090087097

1 reference

17 August 2017

0 references

1 reference

17 August 2017

PubMed publication ID

10792036

1 reference