Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes (Q24652779)

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O de Bouteiller

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Y J Liu

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K Potter

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J D Capra

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V Pascual

Journal of Experimental Medicine

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language of work or name

English

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publication date

5 January 1998

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published in

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volume

187

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issue

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page(s)

59-70

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Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

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Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

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Somatic hypermutation

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Clusters of point mutations are found exclusively around rearranged antibody variable genes

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Antibody diversity: somatic hypermutation of rearranged VH genes

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Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday

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Patterns of somatic mutations in immunoglobulin variable genes

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The smaller human VH gene families display remarkably little polymorphism

28 September 2017

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Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

28 September 2017

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Frameshift mutation: determinants of specificity

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Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication

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Biological activity of a human monoclonal antibody to Bordetella pertussis lipooligosaccharide

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Maturation and dispersal of B-cell clones during T cell-dependent antibody responses

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The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

28 September 2017

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Mismatch repair as a source of mutations in non-dividing cells

28 September 2017

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Molecular characterization of human antibodies to bacterial antigens: utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families

28 September 2017

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The cross-reactive idiotopes recognized by the monoclonal antibodies 9G4 and LC1 are located in framework region 1 of two non-overlapping subsets of human VH4 family encoded antibodies

28 September 2017

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The Somatic Hypermutation Activity of a Follicular Lymphoma Links to Large Insertions and Deletions of Immunoglobulin Genes

28 September 2017

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Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches

28 September 2017

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Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs.

30 May 2018

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Low frequencies of somatic mutation in two expressed V kappa genes: unequal distribution of mutation in 5' and 3' flanking regions

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The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse

30 May 2018

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Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

30 May 2018

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Distribution of mutations around rearranged heavy-chain antibody variable-region genes

30 May 2018

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Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles

30 May 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

30 May 2018

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Reciprocal homologous recombination in or near antibody VDJ genes

30 May 2018

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A DNA repair abnormality specific for rearranged immunoglobulin variable genes in germinal center B cells

21 January 2018

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Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells

21 January 2018

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Codon bias targets mutation.

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Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes

21 January 2018

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12 December 2020

Five human mature B cell subsets

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12 December 2020

Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts

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12 December 2020

Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes

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12 December 2020