Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. (Q39809953)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9788964%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

title

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors (English)

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5 December 2019

0 references

1 reference

chronic lymphocytic leukemia

1 reference

1 reference

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5 December 2019

F Ghiotto

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5 December 2019

S Hashimoto

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5 December 2019

B Sellars

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5 December 2019

A Valetto

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5 December 2019

S L Allen

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5 December 2019

P Schulman

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5 December 2019

V P Vinciguerra

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5 December 2019

K Rai

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5 December 2019

L Z Rassenti

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5 December 2019

T J Kipps

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5 December 2019

G Dighiero

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5 December 2019

H W Schroeder

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5 December 2019

M Ferrarini

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5 December 2019

N Chiorazzi

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5 December 2019

language of work or name

English

0 references

publication date

1 October 1998

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Journal of Clinical Investigation

5 December 2019

published in

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5 December 2019

volume

102

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5 December 2019

issue

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5 December 2019

page(s)

1515-1525

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Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences.

5 December 2019

cites work

1 reference

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22 September 2017

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22 September 2017

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Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.

22 September 2017

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IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

22 September 2017

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Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number

22 September 2017

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High-frequency representation of a single VH gene in the expressed human B cell repertoire

22 September 2017

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Molecular analysis of VH and VL regions expressed in IgG-bearing chronic lymphocytic leukemia (CLL): further evidence that CLL is a heterogeneous group of tumors

22 September 2017

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The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A

22 September 2017

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Mutational analysis of an autoantibody: differential binding and pathogenicity

22 September 2017

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Immunoglobulin genes in chronic lymphocytic leukemia.

22 September 2017

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Analysis of somatic mutation in five B cell subsets of human tonsil

22 September 2017

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The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

22 September 2017

1 reference

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Differential usage of an autoantibody-associated VH gene, VH4-21, by human B-cell tumors

22 September 2017

1 reference

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Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells

22 September 2017

1 reference

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The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

22 September 2017

1 reference

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Polymorphism and utilization of human VH Genes.

22 September 2017

1 reference

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Analysis of immunoglobulin VH gene repertoire by an anchored PCR-ELISA.

22 September 2017

1 reference

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Single amino acid substitution altering antigen-binding specificity

22 September 2017

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Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy

22 September 2017

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Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia

22 September 2017

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Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia

22 September 2017

1 reference

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Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype

22 September 2017

1 reference

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The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma

22 September 2017

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VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire

22 September 2017

1 reference

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Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype

22 September 2017

1 reference

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Developmental origins, specificities and immunoglobulin gene biases of murine Ly-1 B cells

22 September 2017

1 reference

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Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia

22 September 2017

1 reference

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Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

22 September 2017

1 reference

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Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features

17 June 2018

1 reference

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An endogenous sialoprotein and a bacterial B cell superantigen compete in their VH family-specific binding interactions with human Igs.

17 June 2018

1 reference

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V kappa gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the V kappa locus and do not show somatic mutation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

A single engineered amino acid substitution changes antibody fine specificity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Representation of rearranged VH gene segments in the human adult antibody repertoire

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Common clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richter's syndrome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Developmentally controlled expression of immunoglobulin VH genes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Early restriction of the human antibody repertoire

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Biased usage of variable and constant-region Ig genes by IgG+, CD5+ human leukemic B cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: intraclonal stability is frequent but not constant

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509001

The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin

20 August 2018

1 reference

12 December 2020

B cells of chronic lymphatic leukemia express V genes in unmutated form

1 reference

12 December 2020

Differential usage of an Ig heavy chain variable region gene by human B-cell tumors

1 reference

12 December 2020

Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma

1 reference

12 December 2020

Surface phenotype and immunoglobulin heavy chain gene usage in chronic B-cell leukemias

1 reference

12 December 2020

B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro

1 reference

12 December 2020

Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification

1 reference

12 December 2020

VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4-34) gene

1 reference

12 December 2020

Evolutionary nucleotide replacements in DNA

1 reference

12 December 2020

Junctional diversity is essential to antibody activity

1 reference

12 December 2020

The role of clonal selection and somatic mutation in autoimmunity

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI3009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9788964%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9788964%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

PubMed publication ID

9788964

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9788964%20AND%20SRC:MED&resulttype=core&format=json