The dynamic epigenome and its implications in toxicology (Q36901377)

17 August 2017

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title

The dynamic epigenome and its implications in toxicology (English)

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17 August 2017

Moshe Szyf

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17 August 2017

publication date

3 August 2007

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17 August 2017

published in

Toxicological Sciences

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17 August 2017

volume

100

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17 August 2017

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17 August 2017

page(s)

7-23

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Epigenetic transgenerational actions of endocrine disruptors and male fertility

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

An unmethylated 3' promoter-proximal region is required for efficient transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

HIDden targets of microRNAs for growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

A mammalian protein with specific demethylase activity for mCpG DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Dnmt3L and the establishment of maternal genomic imprints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Demethylase activity is directed by histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Phosphorylated CREB binds specifically to the nuclear protein CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Epigenetics and microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Modulation of plasmid DNA methylation and expression in zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Valproate induces replication-independent active DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Promoter-specific activation and demethylation by MBD2/demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Metastable epialleles, imprinting, and the fetal origins of adult diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methylation profiling of human chromosomes 6, 20 and 22

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methylation in cancer: too much, but also too little

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The role of folic acid and Vitamin B12 in genomic stability of human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Structure of nucleosome core particles of chromatin

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Nongenomic transmission across generations of maternal behavior and stress responses in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone acetylation in chromatin structure and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Epigenetics, histone H3 variants, and the inheritance of chromatin states

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Re-SET-ting heterochromatin by histone methyltransferases

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Translating the Histone Code

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone deacetylase as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Roles of histone acetyltransferases and deacetylases in gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

B cell-specific demethylation: a novel role for the intronic kappa chain enhancer sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methylation in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Regulation of DNA methylation by the Ras signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Maternal care as a model for experience-dependent chromatin plasticity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Covalent modification of DNA regulates memory formation

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The transcriptional coactivators p300 and CBP are histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Active demethylation of the paternal genome in the mouse zygote

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Changes in the chromatin structure of Drosophila glue genes accompany developmental cessation of transcription in wild type and transformed strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methylation is a reversible biological signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

CpG methylation, chromatin structure and gene silencing-a three-way connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Distribution of 5-methylcytosine in chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA Methylation and Gene Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methylation patterns. Formation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Epigenetic activation of tumor suppressor microRNAs in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone variants meet their match

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Polycomb silencing mechanisms and the management of genomic programmes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Functional cooperation between HP1 and DNMT1 mediates gene silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Pattern of methylation of two genes coding for housekeeping functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Towards a pharmacology of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Nucleotide-sequence-specific de novo methylation in a somatic murine cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The absence of detectable methylated bases in Drosophila melanogaster DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Regulation of higher-order chromatin structures by nucleosome-remodelling factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

In psychosis, cortical interneurons overexpress DNA-methyltransferase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone acetylation: chromatin in action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Transposable elements: targets for early nutritional effects on epigenetic gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Epigenetic programming by maternal behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Histone deacetylase: a regulator of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

microRNAs as oncogenes and tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression: Characterization of Intracellular Mediators and Potential Genomic Target Sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM177

S-adenosyl-L-methionine for alcoholic liver diseases

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1002/14651858.CD002235.PUB2

Identifiers

DOI

10.1093/TOXSCI/KFM177

1 reference

17 August 2017

1 reference