Histone deacetylase as a therapeutic target (Q34336927)

1 August 2017

title

Histone deacetylase as a therapeutic target (English)

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1 August 2017

Krämer OH

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1 August 2017

Göttlicher M

series ordinal

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1 August 2017

Heinzel T

series ordinal

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1 August 2017

publication date

1 September 2001

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Trends in Endocrinology and Metabolism

1 August 2017

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

294-300

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Covalent modifications of histones: expression from chromatin templates

1 August 2017

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The language of covalent histone modifications

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What's up and down with histone deacetylation and transcription?

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The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

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Histone deacetylases, transcriptional control, and cancer

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The human histone deacetylase family

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4

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SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions?

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Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

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Altered retinoic acid receptors.

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

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7 January 2021

Multiple regions of ETO cooperate in transcriptional repression

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Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

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Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor

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Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

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Histone acetylation and cancer

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7 January 2021

Butyrate and phenylacetate as differentiating agents: practical problems and opportunities.

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Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies

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Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

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7 January 2021

Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

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7 January 2021

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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7 January 2021

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

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7 January 2021

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

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Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

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7 January 2021

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

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7 January 2021

Effects of retinoic acid and sodium butyrate on gene expression, histone acetylation and inhibition of proliferation of melanoma cells

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7 January 2021

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

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7 January 2021

Butyrate as a differentiating agent: pharmacokinetics, analogues and current status

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7 January 2021

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

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7 January 2021

Induction of MAGE-3 expression in lung and esophageal cancer cells

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7 January 2021

Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

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7 January 2021

Trichostatin A Induces Morphological Changes and Gelsolin Expression by Inhibiting Histone Deacetylase in Human Carcinoma Cell Lines

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7 January 2021

Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites

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7 January 2021

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

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7 January 2021

p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells

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7 January 2021

Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors

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7 January 2021

Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation

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7 January 2021

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

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7 January 2021

Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells

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7 January 2021

IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells.

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7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

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7 January 2021

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7 January 2021

Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells

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7 January 2021

Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells

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7 January 2021

bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

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7 January 2021

Rb interacts with histone deacetylase to repress transcription

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7 January 2021

Butyrate inhibits seeding and growth of colorectal metastases to the liver in mice

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7 January 2021

Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model.

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7 January 2021

Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukemia in a child.

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7 January 2021

Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors

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7 January 2021

Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells

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7 January 2021

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

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7 January 2021

10.1016/S1043-2760(01)00438-6

Identifiers

DOI

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1 August 2017

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