AID-initiated purposeful mutations in immunoglobulin genes (Q36845671)

16 August 2017

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title

AID-initiated purposeful mutations in immunoglobulin genes (English)

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16 August 2017

Myron F Goodman

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16 August 2017

Matthew D Scharff

series ordinal

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16 August 2017

Floyd E Romesberg

series ordinal

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16 August 2017

publication date

1 January 2007

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16 August 2017

published in

Advances in Immunology

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16 August 2017

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16 August 2017

page(s)

127-155

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Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex

16 August 2017

cites work

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Involvement of Rad18 in somatic hypermutation

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

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7 January 2021

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

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7 January 2021

A two-phase model of B-cell activation

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Intrinsic and extrinsic factors in protein antigenic structure

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7 January 2021

The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination

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7 January 2021

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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7 January 2021

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

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7 January 2021

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

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7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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7 January 2021

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

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7 January 2021

APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.

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7 January 2021

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

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7 January 2021

Probing the human natural autoantibody repertoire using an immunoscreening approach

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7 January 2021

APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation

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7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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7 January 2021

AID mediates hypermutation by deaminating single stranded DNA.

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7 January 2021

Conformational isomerism and the diversity of antibodies

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7 January 2021

The energy landscape in non-biological and biological molecules

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7 January 2021

Conformational substates in proteins

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7 January 2021

The Energy Landscapes and Motions of Proteins

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7 January 2021

Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma

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7 January 2021

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

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7 January 2021

How do site-specific DNA-binding proteins find their targets?

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7 January 2021

An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded fab and a deoxynucleotide-fab complex

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7 January 2021

Solvent Accessibility of the Phycocyanobilin Chromophore in the α Subunit of C-Phycocyanin: Implications for a Molecular Mechanism for Inertial Protein-Matrix Solvation Dynamics

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7 January 2021

AID: how does it aid antibody diversity?

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7 January 2021

Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution

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7 January 2021

Antibody multispecificity mediated by conformational diversity

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7 January 2021

Regulation of IgG antibody responses by epitope density and CD21-mediated costimulation

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7 January 2021

Protein dynamics and the immunological evolution of molecular recognition.

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7 January 2021

The targeting of somatic hypermutation

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7 January 2021

Evolutionary chemistry: getting there from here

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7 January 2021

Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Mechanisms of chromosomal translocations in B cell lymphomas

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7 January 2021

MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification

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7 January 2021

The generation of antibody diversity through somatic hypermutation and class switch recombination

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7 January 2021

Why do B cells mutate their immunoglobulin receptors?

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7 January 2021

Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

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7 January 2021

Immunoglobulin gene diversification

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7 January 2021

Somatic hypermutation of the AID transgene in B and non-B cells

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7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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7 January 2021

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

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7 January 2021

A very high level of crossreactivity is an essential feature of the T-cell receptor

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7 January 2021

Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation

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7 January 2021

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

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7 January 2021

Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement

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7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

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7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Transcription-coupled events associating with immunoglobulin switch region chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Targeting of somatic hypermutation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Histone modifications associated with somatic hypermutation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Constitutive expression of AID leads to tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Monomeric APOBEC3G is catalytically active and has antiviral activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

The immunological evolution of catalysis

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7 January 2021

Molecular Architecture and Biological Reactions

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7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

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7 January 2021

Reward versus risk: DNA cytidine deaminases triggering immunity and disease

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

DNA deaminases AID and APOBEC3G act processively on single-stranded DNA

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Error-prone candidates vie for somatic mutation

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7 January 2021

The APOBEC-2 crystal structure and functional implications for the deaminase AID

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7 January 2021

The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

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7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

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7 January 2021

Clonal selection and learning in the antibody system

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7 January 2021

Switching on chromosomal translocations

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7 January 2021

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

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7 January 2021

What role for AID: mutator, or assembler of the immunoglobulin mutasome?

1 reference

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7 January 2021

Structural evidence for induced fit as a mechanism for antibody-antigen recognition

1 reference

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7 January 2021

Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process

1 reference

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7 January 2021

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

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7 January 2021

Immunological origins of binding and catalysis in a Diels-Alderase antibody

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7 January 2021

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells

1 reference

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7 January 2021

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled

1 reference

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7 January 2021

Separate domains of AID are required for somatic hypermutation and class-switch recombination

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7 January 2021

Autoimmunity versus horror autotoxicus: the struggle for recognition

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7 January 2021

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

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7 January 2021

Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A

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7 January 2021

Molecular recognition in antibody-antigen complexes

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7 January 2021

Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication

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7 January 2021

Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches

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7 January 2021

Codon bias targets mutation.

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7 January 2021

Genome-wide somatic hypermutation

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7 January 2021

Identification of a specific domain required for dimerization of activation-induced cytidine deaminase

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7 January 2021

AID-dependent histone acetylation is detected in immunoglobulin S regions

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7 January 2021

Structural insights into the evolution of an antibody combining site

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7 January 2021

1.85 A structure of anti-fluorescein 4-4-20 Fab

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7 January 2021

Harmful somatic mutations: lessons from the dark side

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7 January 2021

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

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7 January 2021

A comparative analysis of the immunological evolution of antibody 28B4

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7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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7 January 2021

Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994005-X

7 January 2021

How soft is a protein? A protein dynamics force constant measured by neutron scattering.

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7 January 2021

Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics

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7 January 2021

10.1016/S0065-2776(06)94005-X

Identifiers

DOI

1 reference

16 August 2017

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