Genome-wide somatic hypermutation (Q33905110)

29 July 2017

title

Genome-wide somatic hypermutation (English)

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29 July 2017

Clifford L Wang

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29 July 2017

Ryan A Harper

series ordinal

1 reference

29 July 2017

Matthias Wabl

series ordinal

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29 July 2017

publication date

29 April 2004

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

101

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29 July 2017

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29 July 2017

page(s)

7352-7356

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Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

What role for AID: mutator, or assembler of the immunoglobulin mutasome?

28 July 2018

1 reference

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Immunology. One AID to unite them all.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Somatic hypermutation of antibody genes: a hot spot warms up.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Enhancers of hypermutation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Amplification and sequence analysis of DNA flanking integrated proviruses by a simple two-step polymerase chain reaction method.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Clusters of point mutations are found exclusively around rearranged antibody variable genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Antibody diversity: somatic hypermutation of rearranged VH genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Somatic mutation in constant regions of mouse lambda 1 light chains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Immunity through DNA deamination

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

An immunoglobulin mutator that targets G.C base pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Constitutive expression of AID leads to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Mismatch repair co-opted by hypermutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Variability in the Lambda Light Chain Sequences of Mouse Antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=409922

Origin of Antibody Variation

29 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

Cis-acting sequences that affect somatic hypermutation of Ig genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402009101

21 January 2018

Identifiers

DOI

10.1073/PNAS.0402009101

1 reference

29 July 2017

0 references

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29 July 2017

1 reference