Technology Insight: querying the genome with microarrays--progress and hope for neurological disease (Q36577260)

15 August 2017

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title

Technology Insight: querying the genome with microarrays--progress and hope for neurological disease (English)

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15 August 2017

Daniel H Geschwind

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15 August 2017

Giovanni Coppola

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15 August 2017

language of work or name

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1 March 2006

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Nature Clinical Practice Neurology

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

147-158

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describes a project that uses

15 August 2017

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Mutational analysis using oligonucleotide microarrays

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Gene Expression Profiling in Ataxin-3 Expressing Cell Lines Reveals Distinct Effects of Normal and Mutant Ataxin-3

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Quantitative monitoring of gene expression patterns with a complementary DNA microarray

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7 January 2021

Expression monitoring by hybridization to high-density oligonucleotide arrays

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7 January 2021

Systems biology 101--what you need to know

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7 January 2021

DNA microarrays: translation of the genome from laboratory to clinic

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7 January 2021

Molecular interactions on microarrays

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7 January 2021

DNA arrays and neurobiology--what's new and what's next?

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7 January 2021

Progress in the use of microarray technology to study the neurobiology of disease

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7 January 2021

Applications of DNA microarrays in biology

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7 January 2021

Comparative genomic hybridization

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7 January 2021

Large-scale genotyping of complex DNA.

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7 January 2021

Mice, microarrays, and the genetic diversity of the brain

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7 January 2021

Modulation of polyglutamine-induced cell death by genes identified by expression profiling

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7 January 2021

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

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7 January 2021

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

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7 January 2021

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

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7 January 2021

A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease.

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7 January 2021

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

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7 January 2021

Gene expression in Huntington's disease skeletal muscle: a potential biomarker

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7 January 2021

Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice

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7 January 2021

Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification.

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7 January 2021

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain

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7 January 2021

Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations

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7 January 2021

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

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7 January 2021

Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice

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7 January 2021

Modelling brain diseases in mice: the challenges of design and analysis

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7 January 2021

Exercise your amyloid

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7 January 2021

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia.

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7 January 2021

Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

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7 January 2021

DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes

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7 January 2021

Presenilin-1-dependent transcriptome changes.

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7 January 2021

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

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7 January 2021

Model-guided microarray implicates the retromer complex in Alzheimer's disease

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7 January 2021

Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays

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7 January 2021

Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions

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7 January 2021

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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7 January 2021

A genetic analysis of neural progenitor differentiation

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7 January 2021

Mapping of genetic and epigenetic regulatory networks using microarrays

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7 January 2021

A general framework for weighted gene co-expression network analysis

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7 January 2021

Gene expression profiling of gliomas strongly predicts survival

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7 January 2021

DNA-microarray analysis of brain cancer: molecular classification for therapy

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7 January 2021

Gene expression phenotype in heterozygous carriers of ataxia telangiectasia

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease

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7 January 2021

Blood gene expression profiling of neurologic diseases: a pilot microarray study

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7 January 2021

Neonatal screening by DNA microarray: spots and chips

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7 January 2021

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings

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7 January 2021

Accessing genetic information with high-density DNA arrays.

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7 January 2021

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors

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7 January 2021

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

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7 January 2021

Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations

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7 January 2021

Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA.

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7 January 2021

Segmental duplications and copy-number variation in the human genome

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7 January 2021

Large-scale copy number polymorphism in the human genome

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7 January 2021

Array comparative genomic hybridization and its applications in cancer

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7 January 2021

Development of a comparative genomic hybridization microarray and demonstration of its utility with 25 well-characterized 1p36 deletions.

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7 January 2021

Large-scale variation among human and great ape genomes determined by array comparative genomic hybridization

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Genomewide linkage searches for Mendelian disease loci can be efficiently conducted using high-density SNP genotyping arrays

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Whole-genome patterns of common DNA variation in three human populations

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

A haplotype map of the human genome

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7 January 2021

Complement factor H polymorphism in age-related macular degeneration

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7 January 2021

Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.

1 reference

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7 January 2021

High-resolution whole-genome association study of Parkinson disease.

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7 January 2021

A genome-wide scalable SNP genotyping assay using microarray technology

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Toward genome-wide SNP genotyping

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

High-throughput variation detection and genotyping using microarrays

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform

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7 January 2021

Genome sequencing in microfabricated high-density picolitre reactors

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Gene expression profiles in a transgenic animal model of fragile X syndrome

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Friedreich ataxia: the oxidative stress paradox

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7 January 2021

Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes

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7 January 2021

Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells.

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7 January 2021

Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.

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7 January 2021

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

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7 January 2021

Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine

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7 January 2021

Gene expression profile analysis of lymphocytes from Alzheimer's patients

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7 January 2021

Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons

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7 January 2021

Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

A gene expression profile of Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling

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7 January 2021

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

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7 January 2021

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis

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7 January 2021

Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis

1 reference

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7 January 2021

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0133

7 January 2021

New developments in high-throughput resequencing and variation detection using high density microarrays

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7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0133

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Dimensions Publication ID

15 August 2017

1018399920

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