BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. (Q36445905)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18056841%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia (English)

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29 December 2019

1 reference

Victoria Del Gaizo Moore

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29 December 2019

Krysta D Schlis

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29 December 2019

Stephen E Sallan

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29 December 2019

Scott A Armstrong

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29 December 2019

Anthony Letai

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29 December 2019

language of work or name

English

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publication date

4 December 2007

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29 December 2019

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29 December 2019

volume

111

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29 December 2019

issue

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29 December 2019

page(s)

2300-2309

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

29 December 2019

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30 September 2017

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

30 September 2017

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

30 September 2017

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

30 September 2017

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30 September 2017

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30 September 2017

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Bim is a suppressor of Myc-induced mouse B cell leukemia

30 September 2017

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Cell death: critical control points

30 September 2017

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Bad-deficient mice develop diffuse large B cell lymphoma

30 September 2017

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New agents in the treatment of acute lymphocytic leukaemia

30 September 2017

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Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase

30 September 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

30 September 2017

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

30 September 2017

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Modelling the molecular circuitry of cancer

30 September 2017

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

30 September 2017

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

30 September 2017

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

30 September 2017

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PUMA, a novel proapoptotic gene, is induced by p53

30 September 2017

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

30 September 2017

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

30 September 2017

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30 September 2017

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins

30 September 2017

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30 September 2017

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Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene

30 September 2017

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30 September 2017

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

30 September 2017

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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

28 June 2018

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

28 June 2018

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

28 June 2018

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21 September 2018

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Abnormalities of the P53, MDM2, BCL2 and BAX genes in acute leukemias.

21 September 2018

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Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

21 September 2018

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Assessment of bcl-2 expression as modulator of fas mediated apoptosis in acute leukemia.

21 September 2018

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 September 2018

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Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

21 September 2018

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis

21 September 2018

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Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

21 September 2018

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BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance

21 September 2018

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12 December 2020

A matter of life and death

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12 December 2020

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

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12 December 2020

Expression of BCL-2 proto-oncogene in adult acute lymphoblastic leukemia

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12 December 2020

Expression of apoptosis regulators Bcl-2 and Bax in childhood acute lymphoblastic leukemia

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12 December 2020

Tumor growth need not be driven by rare cancer stem cells

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Traps to catch unwary oncogenes

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12 December 2020

10.1182/BLOOD-2007-06-098012

Identifiers

DOI

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29 December 2019

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29 December 2019

PubMed publication ID

18056841

1 reference

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