Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins (Q34612753)

3 August 2017

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title

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins (English)

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3 August 2017

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Strasser A

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3 August 2017

Puthalakath H

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3 August 2017

publication date

1 May 2002

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Cell Death & Differentiation

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

505-512

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

3 August 2017

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7 January 2021

Death receptors: signaling and modulation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The Bcl-2 protein family: arbiters of cell survival

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Mitochondria and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

BID: a novel BH3 domain-only death agonist

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Mechanisms and Functions of Cell Death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bim: a novel member of the Bcl-2 family that promotes apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Anchorage dependence, integrins, and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400998

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4400998

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Dimensions Publication ID

3 August 2017

1000342485

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