(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. (Q36294009)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15771421%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15771421%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

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9 January 2020

Zhan-Guo Gao

1 reference

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9 January 2020

Susanna Tchilibon

1 reference

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9 January 2020

Bhalchandra V Joshi

1 reference

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9 January 2020

Soo-Kyung Kim

1 reference

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9 January 2020

Heng T Duong

series ordinal

1 reference

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9 January 2020

language of work or name

English

0 references

publication date

1 March 2005

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Journal of Medicinal Chemistry

9 January 2020

published in

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9 January 2020

volume

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9 January 2020

issue

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9 January 2020

page(s)

1745-1758

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15771421%20AND%20SRC:MED&resulttype=core&format=json

A new synthetic route to (North)-methanocarba nucleosides designed as A3 adenosine receptor agonists.

9 January 2020

cites work

1 reference

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Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

30 September 2017

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A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis

30 September 2017

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Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.

30 September 2017

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2-Substitution of Adenine Nucleotide Analogues Containing a Bicyclo[3.1.0]hexane Ring System Locked in a Northern Conformation: Enhanced Potency as P2Y1 Receptor Antagonists

30 September 2017

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Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury

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30 September 2017

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A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway

30 September 2017

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N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors

30 September 2017

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Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

30 September 2017

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Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors

30 September 2017

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3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor

30 September 2017

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N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands

30 September 2017

1 reference

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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

30 September 2017

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International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

30 September 2017

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Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications

30 September 2017

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2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor

30 September 2017

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A partial agonist of the A(1)-adenosine receptor selectively slows AV conduction in guinea pig hearts

30 September 2017

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Crystal structure of rhodopsin: A G protein-coupled receptor

30 September 2017

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A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists

30 September 2017

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Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.

30 September 2017

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Biochemical methods for detection and measurement of cyclic AMP and adenylyl cyclase activity.

30 September 2017

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N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor

30 September 2017

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The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles

30 September 2017

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Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position

30 September 2017

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A physiological role of the adenosine A3 receptor: sustained cardioprotection

30 September 2017

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30 September 2017

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Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists

30 September 2017

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2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors

30 September 2017

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30 September 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

30 September 2017

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30 September 2017

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The influence of adenosine A3 receptor agonist: IB-MECA, on scopolamine- and MK-801-induced memory impairment.

30 September 2017

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Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

29 June 2018

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Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation

29 June 2018

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Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice

22 September 2018

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Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.

22 September 2018

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Activity of the A3 adenosine receptor gene promoter in transgenic mice: characterization of previously unidentified sites of expression

22 September 2018

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Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

22 September 2018

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Knockout of A3 adenosine receptors reduces mouse intraocular pressure

22 September 2018

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Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor

22 September 2018

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Treatment of glomerulonephritis with metrifudil. Preliminary report

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15771421

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12 December 2020

based on heuristic

Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15771421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15771421

inferred from PubMed ID database lookup

12 December 2020

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Identifiers

DOI

10.1021/JM049580R

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15771421%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15771421%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

15771421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15771421%20AND%20SRC:MED&resulttype=core&format=json